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Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy

Istituto di Bioimmagini e Fisiologia Molecolare-Consiglio Nazionale delle Ricerche (IBFM-CNR), 90015 Cefalù (PA), Italy
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These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(21), 5267; https://doi.org/10.3390/ijms20215267
Received: 25 September 2019 / Revised: 18 October 2019 / Accepted: 22 October 2019 / Published: 23 October 2019
The improvement of diagnostic techniques and the efficacy of new therapies in clinical practice have allowed cancer patients to reach a higher chance to be cured together with a better quality of life. However, tumors still represent the second leading cause of death worldwide. On the contrary, chemotherapy and radiotherapy (RT) still lack treatment plans which take into account the biological features of tumors and depend on this for their response to treatment. Tumor cells’ response to RT is strictly-connected to their radiosensitivity, namely, their ability to resist and to overcome cell damage induced by ionizing radiation (IR). For this reason, radiobiological research is focusing on the ability of chemical compounds to radiosensitize cancer cells so to make them more responsive to IR. In recent years, the interests of researchers have been focused on natural compounds that show antitumoral effects with limited collateral issues. Moreover, nutraceuticals are easy to recover and are thus less expensive. On these bases, several scientific projects have aimed to test also their ability to induce tumor radiosensitization both in vitro and in vivo. The goal of this review is to describe what is known about the role of nutraceuticals in radiotherapy, their use and their potential application. View Full-Text
Keywords: nutraceuticals; radiotherapy; cancer nutraceuticals; radiotherapy; cancer
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MDPI and ACS Style

Calvaruso, M.; Pucci, G.; Musso, R.; Bravatà, V.; Cammarata, F.P.; Russo, G.; Forte, G.I.; Minafra, L. Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy. Int. J. Mol. Sci. 2019, 20, 5267. https://doi.org/10.3390/ijms20215267

AMA Style

Calvaruso M, Pucci G, Musso R, Bravatà V, Cammarata FP, Russo G, Forte GI, Minafra L. Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy. International Journal of Molecular Sciences. 2019; 20(21):5267. https://doi.org/10.3390/ijms20215267

Chicago/Turabian Style

Calvaruso, Marco; Pucci, Gaia; Musso, Rosa; Bravatà, Valentina; Cammarata, Francesco P.; Russo, Giorgio; Forte, Giusi I.; Minafra, Luigi. 2019. "Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy" Int. J. Mol. Sci. 20, no. 21: 5267. https://doi.org/10.3390/ijms20215267

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