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Adipogenesis: A Necessary but Harmful Strategy
Open AccessArticle

Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children

1
Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, 89075 Ulm, Germany
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Division of Pediatric Surgery, Department of Surgery, University Medical Center Ulm, 89075 Ulm, Germany
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Institute of Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany
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Institute of Pathology, University Medical Center Ulm, 89081 Ulm, Germany
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Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, 89075 Ulm, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5204; https://doi.org/10.3390/ijms20205204
Received: 1 September 2019 / Revised: 4 October 2019 / Accepted: 16 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Adipogenesis and Adipose Tissue Metabolism)
The growth of adipose tissue and its vasculature are tightly associated. Angiogenic factors have been linked to obesity, yet little is known about their expression during early childhood. To identify associations of angiogenic factors with characteristics on individual and tissue level, subcutaneous white adipose tissue samples were taken from 45 children aged 0–9 years undergoing elective surgery. We measured the expression of vascular endothelial growth factor A (VEFGA), fibroblast growth factor 1 and 2 (FGF1, FGF2), angiopoietin 1 and 2 (ANGPT1, ANGPT2), TEK receptor tyrosine kinase (TEK), and von Willebrand factor (VWF). In addition, we determined the mean adipocyte size in histologic tissue sections. We found positive correlations of age with FGF1 and FGF2 and a negative correlation with ANGPT2, with pronounced differences in the first two years of life. FGF1, FGF2, and ANGPT1 correlated positively with adipocyte size. Furthermore, we identified a correlation of ANGPT1 and TEK with body mass index-standard deviation score (BMI-SDS), a measure to define childhood obesity. Except for ANGPT2, all angiogenic factors correlated positively with the endothelial marker VWF. In sum, our findings suggest that differences related to BMI-SDS begin early in childhood, and the analyzed angiogenic factors possess distinct roles in adipose tissue biology. View Full-Text
Keywords: adipose tissue; angiogenesis; adipogenesis; obesity; remodeling; vasculature adipose tissue; angiogenesis; adipogenesis; obesity; remodeling; vasculature
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Gaebler, N.; Haggenmüller, B.; Kapapa, M.; Serra, A.; Tews, D.; Funcke, J.-B.; Brandt, S.; Ioannidis, V.; Schön, M.; Möller, P.; Debatin, K.-M.; Wabitsch, M.; Fischer-Posovszky, P. Age- and BMI-Associated Expression of Angiogenic Factors in White Adipose Tissue of Children. Int. J. Mol. Sci. 2019, 20, 5204.

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