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Article

Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles

1
Department of Chemical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University) Varanasi, Varanasi, Uttar Pradesh 221005, India
2
Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University) Varanasi, Varanasi, Uttar Pradesh 221005, India
3
Enhanced Composites and Structures Center, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedfordshire MK43 0AL, UK
4
Department of Chemistry and Biotechnology, ERA Chair of Green Chemistry, Tallinn University of Technology, 12618 Tallinn, Estonia
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(20), 5110; https://doi.org/10.3390/ijms20205110
Received: 21 September 2019 / Revised: 9 October 2019 / Accepted: 12 October 2019 / Published: 15 October 2019
(This article belongs to the Special Issue Carbohydrate Polymers for Pharmaceutical Applications)
Biofilms are the cause of major bacteriological infections in patients. The complex architecture of Escherichia coli (E. coli) biofilm attached to the surface of catheters has been studied and found to depend on the biomaterial’s surface properties. The SEM micrographs and water contact angle analysis have revealed that the nature of the surface affects the growth and extent of E. coli biofilm formation. In vitro studies have revealed that the Gram-negative E. coli adherence to implanted biomaterials takes place in accordance with hydrophobicity, i.e., latex > silicone > polyurethane > stainless steel. Permanent removal of E. coli biofilm requires 50 to 200 times more gentamicin sulfate (G-S) than the minimum inhibitory concentration (MIC) to remove 90% of E. coli biofilm (MBIC90). Here, in vitro eradication of biofilm-associated infection on biomaterials has been done by Eudragit RL100 encapsulated gentamicin sulfate (E-G-S) nanoparticle of range 140 nm. It is 10–20 times more effective against E. coli biofilm-associated infections eradication than normal unentrapped G-S. Thus, Eudragit RL100 mediated drug delivery system provides a promising way to reduce the cost of treatment with a higher drug therapeutic index. View Full-Text
Keywords: E. coli; biofilm; nanoparticle-mediated drug delivery; antibiotics; catheters; biomaterials E. coli; biofilm; nanoparticle-mediated drug delivery; antibiotics; catheters; biomaterials
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MDPI and ACS Style

Pandey, V.K.; Srivastava, K.R.; Ajmal, G.; Thakur, V.K.; Gupta, V.K.; Upadhyay, S.N.; Mishra, P.K. Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles. Int. J. Mol. Sci. 2019, 20, 5110. https://doi.org/10.3390/ijms20205110

AMA Style

Pandey VK, Srivastava KR, Ajmal G, Thakur VK, Gupta VK, Upadhyay SN, Mishra PK. Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles. International Journal of Molecular Sciences. 2019; 20(20):5110. https://doi.org/10.3390/ijms20205110

Chicago/Turabian Style

Pandey, Vivek K., Kumar R. Srivastava, Gufran Ajmal, Vijay K. Thakur, Vijai K. Gupta, Siddh N. Upadhyay, and Pradeep K. Mishra 2019. "Differential Susceptibility of Catheter Biomaterials to Biofilm-Associated Infections and Their Remedy by Drug-Encapsulated Eudragit RL100 Nanoparticles" International Journal of Molecular Sciences 20, no. 20: 5110. https://doi.org/10.3390/ijms20205110

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