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Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behçet’s Disease with Arthritis

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Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, Korea
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Department of Rheumatology, Ajou University School of Medicine, Suwon 16499, Korea
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Department of Microbiology, Ajou University School of Medicine, Suwon 16499, Korea
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Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5044; https://doi.org/10.3390/ijms20205044
Received: 13 August 2019 / Revised: 30 September 2019 / Accepted: 8 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Major Histocompatibility Complex (MHC))
It has been reported Human Leukocyte Antigen (HLA) gene polymorphism is a risk factor for the development of Behçet’s disease (BD). In this study, the association of HLA class II subtypes HLA-DP, DQ, DR, and T cell subsets in BD patients with arthritis was evaluated. Frequencies of HLA-DP, DQ, DR positive cells, and T cell subsets in peripheral blood leukocytes (PBL) were measured by flow cytometric analysis in BD, and compared to rheumatoid arthritis as disease controls and healthy controls. Frequencies of HLA-DQ were significantly decreased in whole PBL and granulocytes of BD active patients as compared to healthy controls. In monocytes populations, proportions of HLA-DR positive cells were significantly increased in BD active patients as compared to healthy controls. Proportions of CD4+CCR7+ and CD8+CCR7+ cells were significantly higher in BD active patients than in BD inactive in whole PBL. Frequencies of CD4+CD62L- and CD8+CD62L- cells in lymphocytes were significantly decreased in active BD than those in inactive BD. There were also correlations between disease activity markers and T cell subsets. Our results revealed HLA-DP, DQ, and DR expressing cell frequencies and several T cell subsets were significantly correlated with BD arthritis symptoms. View Full-Text
Keywords: Behçet’s disease; inflammation; arthritis; HLA-DP; HLA-DQ; HLA-DR Behçet’s disease; inflammation; arthritis; HLA-DP; HLA-DQ; HLA-DR
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Islam, S.M.S.; Kim, H.-A.; Choi, B.; Jung, J.-Y.; Lee, S.-M.; Suh, C.-H.; Sohn, S. Differences in Expression of Human Leukocyte Antigen Class II Subtypes and T Cell Subsets in Behçet’s Disease with Arthritis. Int. J. Mol. Sci. 2019, 20, 5044.

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