Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy
Abstract
:1. Introduction
2. Results and Discussion
2.1. Morphology, Structure, and Optical Properties of Nanoparticles
2.2. Mechanism of Formation of AuS NPs with Control of Star Arms Lengths
2.3. Photothermal Conversion Efficiency of Obtained AuS NPs
2.4. Simulation of PTT of Cancer Cells in the Presence of AuS NPs
3. Materials and Methods
3.1. Materials
3.2. Synthesis of Au Nanostars with Different Lengths of Star Arms
3.3. TEM Characterization
3.4. X-Ray Diffraction
3.5. UV-Vis Spectroscopy
3.6. Cell Culture
3.7. Optical Microscopy Images of Cells
3.8. MTS Assay
3.9. Photothermal Conversion Efficiency Determined from the Time Constant
3.10. Light Source and Cells Irradiation Protocols
3.11. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Parameter (nm) | Samples | |||
---|---|---|---|---|
AuS1 NPs | AuS2 NPs | AuS3 NPs | AuS4 NPs | |
a | 193.75 ± 17.11 | 243.75 ± 15.21 | 293.75 ± 16.76 | 356.27 ± 19.25 |
b | 28.13 ± 4.21 | 19.38 ± 3.17 | 26.25 ± 4.58 | 44.38 ± 6.32 |
c | 3.75 ± 1.02 | 5.63 ± 2.12 | 5.00 ± 1.87 | 6.25 ± 2.09 |
b/c | 7.50 ± 2.28 | 3.44 ± 2.75 | 5.25 ± 3.01 | 7.10 ± 3.02 |
d | 146.38 ± 4.27 | 143.75 ± 3.77 | 140.63 ± 5.08 | 146.21 ± 5.27 |
Lattice Parameter (Å) | Samples | |||
AuS1 NPs | AuS2 NPs | AuS3 NPs | AuS4 NPs | |
4.0740 (6) | 4.0763 (3) | 4.077 (1) | 4.0784 (2) |
η (%) | Samples | |||
---|---|---|---|---|
AuS1 NPs | AuS2 NPs | AuS3 NPs | AuS4 NPs | |
η650 | 38 | 40 | 39 | 44 |
η808 | 33 | 32 | 33 | 34 |
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Depciuch, J.; Stec, M.; Maximenko, A.; Pawlyta, M.; Baran, J.; Parlinska-Wojtan, M. Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy. Int. J. Mol. Sci. 2019, 20, 5011. https://doi.org/10.3390/ijms20205011
Depciuch J, Stec M, Maximenko A, Pawlyta M, Baran J, Parlinska-Wojtan M. Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy. International Journal of Molecular Sciences. 2019; 20(20):5011. https://doi.org/10.3390/ijms20205011
Chicago/Turabian StyleDepciuch, Joanna, Malgorzata Stec, Alexey Maximenko, Miroslawa Pawlyta, Jarek Baran, and Magdalena Parlinska-Wojtan. 2019. "Control of Arms of Au Stars Size and its Dependent Cytotoxicity and Photosensitizer Effects in Photothermal Anticancer Therapy" International Journal of Molecular Sciences 20, no. 20: 5011. https://doi.org/10.3390/ijms20205011