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Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes

Dipartimento Scienze della Vita e dell’Ambiente, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
Institute of Marine Biology, Biotechnology and Aquaculture, Hellenic Center for Marine Research, P.O. Box 2214, Heraklion, 71003 Crete, Greece
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 80078 Pozzuoli, Italy
Canada Excellence Research Chair on the Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Quebec City, QC G1V 0A6, Canada
Nutrigenomics and Fish Endocrinology Group, Institute of Aquaculture Torre de la Sal (IATS-CSIC), 12595 Ribera de Cabanes, Castellón, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(20), 5003;
Received: 18 September 2019 / Revised: 3 October 2019 / Accepted: 5 October 2019 / Published: 10 October 2019
(This article belongs to the Special Issue Mechanisms in Aquatic Toxicology)
Bisphenol A (BPA), a known endocrine disrupting chemical (EDC), was administered by diet to gilthead sea bream (Sparus aurata) in order to study its effects on the endocannabinoid system (ECS) and gonadal steroidogenesis. 2-year-old male gilthead sea bream were fed with two different concentrations of BPA (LOW at 4 and HIGH at 4000 µg/kg body weight for 21 days during the reproductive season. Exposure to 4000 µg BPA/kg bw/day (BPA HIGH) reduced sperm motility and altered the straight-line velocity (VSL) and linearity (LIN). Effects on steroidogenesis were evident, with testosterone (T) being up-regulated by both treatments and 11-ketotestosterone (11-KT) down-regulated by BPA HIGH. Plasma levels of 17β-estradiol (E2) were not affected. The Gonadosomatic Index (GSI) increased in the BPA HIGH group. Interestingly, the levels of endocannabinoids and endocannabinoid-like compounds were significantly reduced after both treatments. Unpredictably, a few changes were noticed in the expression of genes coding for ECS enzymes, while the receptors were up-regulated depending on the BPA dose. Reproductive markers in testis (leptin receptor (lepr), estrogen receptors (era, erb), progesterone receptors (pr) and the gonadotropin releasing hormone receptor (gnrhr)) were up-regulated. BPA induced the up-regulation of the hepatic genes involved in oogenesis (vitellogenin (vtg) and zona pellucida 1 (zp1)). View Full-Text
Keywords: BPA; endocannabinoids; gonads; gilthead sea bream BPA; endocannabinoids; gonads; gilthead sea bream
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MDPI and ACS Style

Forner-Piquer, I.; Fakriadis, I.; Mylonas, C.C.; Piscitelli, F.; Di Marzo, V.; Maradonna, F.; Calduch-Giner, J.; Pérez-Sánchez, J.; Carnevali, O. Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes. Int. J. Mol. Sci. 2019, 20, 5003.

AMA Style

Forner-Piquer I, Fakriadis I, Mylonas CC, Piscitelli F, Di Marzo V, Maradonna F, Calduch-Giner J, Pérez-Sánchez J, Carnevali O. Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes. International Journal of Molecular Sciences. 2019; 20(20):5003.

Chicago/Turabian Style

Forner-Piquer, Isabel, Ioannis Fakriadis, Constantinos C. Mylonas, Fabiana Piscitelli, Vincenzo Di Marzo, Francesca Maradonna, Josep Calduch-Giner, Jaume Pérez-Sánchez, and Oliana Carnevali. 2019. "Effects of Dietary Bisphenol A on the Reproductive Function of Gilthead Sea Bream (Sparus aurata) Testes" International Journal of Molecular Sciences 20, no. 20: 5003.

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