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Int. J. Mol. Sci. 2019, 20(2), 400;

The Crossroad of Ion Channels and Calmodulin in Disease

Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country, 48940 Leioa, Spain
Departamento de Fisiología, Facultad de Farmacia, Universidad del País Vasco (UPV/EHU), 01006 Vitoria-Gasteiz, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 14 December 2018 / Revised: 11 January 2019 / Accepted: 16 January 2019 / Published: 18 January 2019
PDF [1638 KB, uploaded 18 January 2019]


Calmodulin (CaM) is the principal Ca2+ sensor in eukaryotic cells, orchestrating the activity of hundreds of proteins. Disease causing mutations at any of the three genes that encode identical CaM proteins lead to major cardiac dysfunction, revealing the importance in the regulation of excitability. In turn, some mutations at the CaM binding site of ion channels cause similar diseases. Here we provide a summary of the two sides of the partnership between CaM and ion channels, describing the diversity of consequences of mutations at the complementary CaM binding domains. View Full-Text
Keywords: calmodulin; ion channels; channelopathies; calcium calmodulin; ion channels; channelopathies; calcium

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Urrutia, J.; Aguado, A.; Muguruza-Montero, A.; Núñez, E.; Malo, C.; Casis, O.; Villarroel, A. The Crossroad of Ion Channels and Calmodulin in Disease. Int. J. Mol. Sci. 2019, 20, 400.

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