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Article

Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release

1
Dpto. Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012-Seville, Spain
2
PRO2TECS. Departamento de Ingeniería Química, Facultad de Ciencias Experimentales, Campus El Carmen–21071-Huelva, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(2), 398; https://doi.org/10.3390/ijms20020398
Received: 30 December 2018 / Revised: 15 January 2019 / Accepted: 16 January 2019 / Published: 18 January 2019
(This article belongs to the Special Issue Chitins 2018)
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring multi-drug resveratrol (RES). Such systems are endowed with potential therapeutic effects on inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis, through the sustained colonic release of RES from long-lasting mucoadhesive drug depots. The loading of RES into nanoparticles (NPs) was optimized regarding two independent variables: RES/polymer ratio, and temperature. Twenty experiments were carried out and a Box–Behnken experimental design was used to evaluate the significance of these independent variables related to encapsulation efficiency (EE). The enhanced RES EE values were achieved in 24 h at 39 °C and at RES/polymer ratio of 0.75:1 w/w. Sizes and polydispersities of the optimized NPs were studied by dynamic light scattering (DLS). Chitosan (CTS) dispersions containing the RES-loaded NPs were ionically gelled with tricarballylic acid to yield CTS-NPs composites. Macro- and microscopic features (morphology and porosity studied by SEM and spreadability), thermal stability (studied by TGA), and release kinetics of the RES-loaded CTS-NPs were investigated. Release patterns in simulated colon conditions for 48 h displayed significant differences between the NPs (final cumulative drug release: 79–81%), and the CTS-NPs composites (29–34%). View Full-Text
Keywords: colon; inflammatory bowel disease; IBD; drug depot; mucoadhesive; Crohn’s disease; ulcerative colitis; nanoparticles; hydrogels colon; inflammatory bowel disease; IBD; drug depot; mucoadhesive; Crohn’s disease; ulcerative colitis; nanoparticles; hydrogels
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MDPI and ACS Style

Iglesias, N.; Galbis, E.; Díaz-Blanco, M.J.; Lucas, R.; Benito, E.; de-Paz, M.-V. Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release. Int. J. Mol. Sci. 2019, 20, 398. https://doi.org/10.3390/ijms20020398

AMA Style

Iglesias N, Galbis E, Díaz-Blanco MJ, Lucas R, Benito E, de-Paz M-V. Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release. International Journal of Molecular Sciences. 2019; 20(2):398. https://doi.org/10.3390/ijms20020398

Chicago/Turabian Style

Iglesias, Nieves, Elsa Galbis, M. Jesús Díaz-Blanco, Ricardo Lucas, Elena Benito, and M.-Violante de-Paz. 2019. "Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release" International Journal of Molecular Sciences 20, no. 2: 398. https://doi.org/10.3390/ijms20020398

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