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Int. J. Mol. Sci. 2019, 20(2), 317; https://doi.org/10.3390/ijms20020317

Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor Immunotherapy

School of Medicine, Huaqiao University, Quanzhou 362021, Fujian, China
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Received: 15 November 2018 / Revised: 9 January 2019 / Accepted: 11 January 2019 / Published: 14 January 2019
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

Natural killer (NK) cells are innate immune cells that can be activated rapidly to target abnormal and virus-infected cells without prior sensitization. With significant advancements in cell biology technologies, many NK cell lines have been established. Among these cell lines, NK-92 cells are not only the most widely used but have also been approved for clinical applications. Additionally, chimeric antigen receptor-modified NK-92 cells (CAR-NK-92 cells) have shown strong antitumor effects. In this review, we summarize established human NK cell lines and their biological characteristics, and highlight the applications of NK-92 cells and CAR-NK-92 cells in tumor immunotherapy. View Full-Text
Keywords: natural killer cell line; NK-92; chimeric antigen receptor; immunotherapy; tumor natural killer cell line; NK-92; chimeric antigen receptor; immunotherapy; tumor
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Zhang, J.; Zheng, H.; Diao, Y. Natural Killer Cells and Current Applications of Chimeric Antigen Receptor-Modified NK-92 Cells in Tumor Immunotherapy. Int. J. Mol. Sci. 2019, 20, 317.

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