Next Article in Journal
Nutraceutical and Medicinal Potential of the Morus Species in Metabolic Dysfunctions
Next Article in Special Issue
Targeting Autophagy to Overcome Human Diseases
Previous Article in Journal
Selection of Membrane RNA Aptamers to Amyloid Beta Peptide: Implications for Exosome-Based Antioxidant Strategies
Previous Article in Special Issue
Role of Klf4 in the Regulation of Apoptosis and Cell Cycle in Rat Granulosa Cells during the Periovulatory Period
Open AccessReview

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

by Po-Yuan Ke 1,2,3
1
Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
3
Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Int. J. Mol. Sci. 2019, 20(2), 300; https://doi.org/10.3390/ijms20020300
Received: 1 December 2018 / Revised: 5 January 2019 / Accepted: 8 January 2019 / Published: 13 January 2019
Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials through vacuole-mediated sequestration and subsequent delivery to lysosomes for degradation, thus maintaining cellular homeostasis and the integrity of organelles. Autophagy has emerged as playing a critical role in the regulation of liver physiology and the balancing of liver metabolism. Conversely, numerous recent studies have indicated that autophagy may disease-dependently participate in the pathogenesis of liver diseases, such as liver hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. This review summarizes the current knowledge on the functions of autophagy in hepatic metabolism and the contribution of autophagy to the pathophysiology of liver-related diseases. Moreover, the impacts of autophagy modulation on the amelioration of the development and progression of liver diseases are also discussed. View Full-Text
Keywords: autophagy; selective autophagy; liver; liver disease; hepatitis; steatosis; fibrosis; cirrhosis; hepatocellular carcinoma autophagy; selective autophagy; liver; liver disease; hepatitis; steatosis; fibrosis; cirrhosis; hepatocellular carcinoma
Show Figures

Graphical abstract

MDPI and ACS Style

Ke, P.-Y. Diverse Functions of Autophagy in Liver Physiology and Liver Diseases. Int. J. Mol. Sci. 2019, 20, 300.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop