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Int. J. Mol. Sci. 2019, 20(2), 300; https://doi.org/10.3390/ijms20020300

Diverse Functions of Autophagy in Liver Physiology and Liver Diseases

1,2,3
1
Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Liver Research Center, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
3
Division of Allergy, Immunology, and Rheumatology, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan
Received: 1 December 2018 / Revised: 5 January 2019 / Accepted: 8 January 2019 / Published: 13 January 2019
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Abstract

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials through vacuole-mediated sequestration and subsequent delivery to lysosomes for degradation, thus maintaining cellular homeostasis and the integrity of organelles. Autophagy has emerged as playing a critical role in the regulation of liver physiology and the balancing of liver metabolism. Conversely, numerous recent studies have indicated that autophagy may disease-dependently participate in the pathogenesis of liver diseases, such as liver hepatitis, steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma. This review summarizes the current knowledge on the functions of autophagy in hepatic metabolism and the contribution of autophagy to the pathophysiology of liver-related diseases. Moreover, the impacts of autophagy modulation on the amelioration of the development and progression of liver diseases are also discussed. View Full-Text
Keywords: autophagy; selective autophagy; liver; liver disease; hepatitis; steatosis; fibrosis; cirrhosis; hepatocellular carcinoma autophagy; selective autophagy; liver; liver disease; hepatitis; steatosis; fibrosis; cirrhosis; hepatocellular carcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ke, P.-Y. Diverse Functions of Autophagy in Liver Physiology and Liver Diseases. Int. J. Mol. Sci. 2019, 20, 300.

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