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Int. J. Mol. Sci. 2019, 20(2), 297; https://doi.org/10.3390/ijms20020297

Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer

1,†
,
1,2,3,†
,
1,2,3
and
1,3,*
1
Cancer Biology and Epigenetics Group, Research Center, Portuguese Oncology Institute of Porto (CI-IPOP), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
2
Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal
3
Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513 Porto, Portugal
These authors contributed equally to the paper.
*
Author to whom correspondence should be addressed.
Received: 12 December 2018 / Revised: 2 January 2019 / Accepted: 9 January 2019 / Published: 13 January 2019
(This article belongs to the Special Issue Epigenetics of Urological Cancers)
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Abstract

Bladder cancer is one of the most incident neoplasms worldwide, and its treatment remains a significant challenge, since the mechanisms underlying disease progression are still poorly understood. The epithelial to mesenchymal transition (EMT) has been proven to play an important role in the tumorigenic process, particularly in cancer cell invasiveness and metastatic potential. Several studies have reported the importance of epigenetic mechanisms and enzymes, which orchestrate them in several features of cancer cells and, specifically, in EMT. In this paper, we discuss the epigenetic enzymes, protein-coding and non-coding genes, and mechanisms altered in the EMT process occurring in bladder cancer cells, as well as its implications, which allows for improved understanding of bladder cancer biology and for the development of novel targeted therapies. View Full-Text
Keywords: bladder cancer; EMT; miRNA; lncRNA; epigenetics bladder cancer; EMT; miRNA; lncRNA; epigenetics
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Monteiro-Reis, S.; Lobo, J.; Henrique, R.; Jerónimo, C. Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer. Int. J. Mol. Sci. 2019, 20, 297.

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