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Int. J. Mol. Sci. 2019, 20(2), 254; https://doi.org/10.3390/ijms20020254

Overview of the Structure–Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi

1
UMR 152 PharmaDev, Institut de Recherche et Développement, Faculté de Pharmacie, Université Paul Sabatier, 35 Chemin des Maraîchers, 31062 Toulouse, France
2
Centre National de la Recherche Scientifique, Aix-Marseille Univ, Architecture et Fonction des Macromolécules Biologiques, 163 Avenue de Luminy, 13288 Marseille, France
3
Department of Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium
*
Author to whom correspondence should be addressed.
Received: 11 December 2018 / Revised: 29 December 2018 / Accepted: 31 December 2018 / Published: 10 January 2019
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Abstract

To date, a number of mannose-binding lectins have been isolated and characterized from plants and fungi. These proteins are composed of different structural scaffold structures which harbor a single or multiple carbohydrate-binding sites involved in the specific recognition of mannose-containing glycans. Generally, the mannose-binding site consists of a small, central, carbohydrate-binding pocket responsible for the “broad sugar-binding specificity” toward a single mannose molecule, surrounded by a more extended binding area responsible for the specific recognition of larger mannose-containing N-glycan chains. Accordingly, the mannose-binding specificity of the so-called mannose-binding lectins towards complex mannose-containing N-glycans depends largely on the topography of their mannose-binding site(s). This structure–function relationship introduces a high degree of specificity in the apparently homogeneous group of mannose-binding lectins, with respect to the specific recognition of high-mannose and complex N-glycans. Because of the high specificity towards mannose these lectins are valuable tools for deciphering and characterizing the complex mannose-containing glycans that decorate both normal and transformed cells, e.g., the altered high-mannose N-glycans that often occur at the surface of various cancer cells. View Full-Text
Keywords: lectin; plant; fungi; mannose-binding specificity; structure; function; use as tools lectin; plant; fungi; mannose-binding specificity; structure; function; use as tools
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Barre, A.; Bourne, Y.; Van Damme, E.J.M.; Rougé, P. Overview of the Structure–Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. Int. J. Mol. Sci. 2019, 20, 254.

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