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Article

The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus

1
Division of Community and Family Medicine, Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan
2
Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan
3
Central Laboratory, Shino-Test, Sagamihara-City, Kanagawa 252-0331, Japan
4
Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga-City, Saga 849-8501, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4909; https://doi.org/10.3390/ijms20194909
Received: 30 August 2019 / Revised: 1 October 2019 / Accepted: 3 October 2019 / Published: 3 October 2019
(This article belongs to the Special Issue Molecular Research on Obesity and Metabolic Diseases)
The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may be a reasonable index for assessing endothelial dysfunction in type 2 diabetes mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level is correlated with the endothelial function using the Endo-PATTM, a newly developed device, in patients with T2DM. A total of 63 patients with T2DM (mean age: 59 years old) were enrolled in the study. The patients’ serum Lp(a) and oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The reactive hyperemia index (RHI) level was measured using an Endo-PATTM 2000. A correlation analysis between the measured variables was conducted. Among the patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 0.28 (interquartile range: 0.07–0.54), and the mean RHI was 1.8 (standard deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) level was an independent, significant, and inverse variable for the RHI level (β = −0.26, p < 0.05), along with male gender. A high oxLp(a)/Lp(a) level may reflect endothelial dysfunction, as assessed by the Endo-PATTM, in patients with T2DM. Further studies are warranted to confirm the observed findings. View Full-Text
Keywords: endothelium; atherosclerosis; Endo-PAT; oxidative stress; reactive hyperemia; Lp(a) endothelium; atherosclerosis; Endo-PAT; oxidative stress; reactive hyperemia; Lp(a)
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MDPI and ACS Style

Kotani, K.; Yamada, S.; Takahashi, H.; Iwazu, Y.; Yamada, T. The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2019, 20, 4909. https://doi.org/10.3390/ijms20194909

AMA Style

Kotani K, Yamada S, Takahashi H, Iwazu Y, Yamada T. The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus. International Journal of Molecular Sciences. 2019; 20(19):4909. https://doi.org/10.3390/ijms20194909

Chicago/Turabian Style

Kotani, Kazuhiko, Shingo Yamada, Hirokazu Takahashi, Yoshitaka Iwazu, and Toshiyuki Yamada. 2019. "The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus" International Journal of Molecular Sciences 20, no. 19: 4909. https://doi.org/10.3390/ijms20194909

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