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New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes

Biochemistry Area, Health Science Department, Faculty of Health Sciences, Public University of Navarra, 31008 Pamplona, Spain
Diabetes Research Group at Sanford Research, Sioux Falls, SD 57104, USA
Incyte Corporation, Wilmington, DE 19803, USA
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(19), 4789;
Received: 29 August 2019 / Revised: 18 September 2019 / Accepted: 20 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Advances in Immunotherapeutic Approaches to Type 1 Diabetes)
Type 1 diabetes mellitus (T1D) is an autoimmune illness that affects millions of patients worldwide. The main characteristic of this disease is the destruction of pancreatic insulin-producing beta cells that occurs due to the aberrant activation of different immune effector cells. Currently, T1D is treated by lifelong administration of novel versions of insulin that have been developed recently; however, new approaches that could address the underlying mechanisms responsible for beta cell destruction have been extensively investigated. The strategies based on immunotherapies have recently been incorporated into a panel of existing treatments for T1D, in order to block T-cell responses against beta cell antigens that are very common during the onset and development of T1D. However, a complete preservation of beta cell mass as well as insulin independency is still elusive. As a result, there is no existing T1D targeted immunotherapy able to replace standard insulin administration. Presently, a number of novel therapy strategies are pursuing the goals of beta cell protection and normoglycemia. In the present review we explore the current state of immunotherapy in T1D by highlighting the most important studies in this field, and envision novel strategies that could be used to treat T1D in the future. View Full-Text
Keywords: diabetes; autoimmunity; insulin; immunotherapy and clinical trials diabetes; autoimmunity; insulin; immunotherapy and clinical trials
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Cabello-Olmo, M.; Araña, M.; Radichev, I.; Smith, P.; Huarte, E.; Barajas, M. New Insights into Immunotherapy Strategies for Treating Autoimmune Diabetes. Int. J. Mol. Sci. 2019, 20, 4789.

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