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Review

Insights into the Functions of LncRNAs in Drosophila

by 1,†, 1,†, 1, 1,2, 1,2, 3 and 1,2,*
1
Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China
2
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China
3
College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(18), 4646; https://doi.org/10.3390/ijms20184646
Received: 20 August 2019 / Revised: 11 September 2019 / Accepted: 11 September 2019 / Published: 19 September 2019
(This article belongs to the Section Molecular Biology)
Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs longer than 200 nucleotides (nt). LncRNAs have high spatiotemporal specificity, and secondary structures have been preserved throughout evolution. They have been implicated in a range of biological processes and diseases and are emerging as key regulators of gene expression at the epigenetic, transcriptional, and post-transcriptional levels. Comparative analyses of lncRNA functions among multiple organisms have suggested that some of their mechanisms seem to be conserved. Transcriptome studies have found that some Drosophila lncRNAs have highly specific expression patterns in embryos, nerves, and gonads. In vivo studies of lncRNAs have revealed that dysregulated expression of lncRNAs in Drosophila may result in impaired embryo development, impaired neurological and gonadal functions, and poor stress resistance. In this review, we summarize the epigenetic, transcriptional, and post-transcriptional mechanisms of lncRNAs and mainly focus on recent insights into the transcriptome studies and biological functions of lncRNAs in Drosophila. View Full-Text
Keywords: long non-coding RNAs; mechanism; Drosophila; transcriptome; biological function long non-coding RNAs; mechanism; Drosophila; transcriptome; biological function
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MDPI and ACS Style

Li, K.; Tian, Y.; Yuan, Y.; Fan, X.; Yang, M.; He, Z.; Yang, D. Insights into the Functions of LncRNAs in Drosophila. Int. J. Mol. Sci. 2019, 20, 4646. https://doi.org/10.3390/ijms20184646

AMA Style

Li K, Tian Y, Yuan Y, Fan X, Yang M, He Z, Yang D. Insights into the Functions of LncRNAs in Drosophila. International Journal of Molecular Sciences. 2019; 20(18):4646. https://doi.org/10.3390/ijms20184646

Chicago/Turabian Style

Li, Keqin; Tian, Yuanliangzi; Yuan, Ya; Fan, Xiaolan; Yang, Mingyao; He, Zhi; Yang, Deying. 2019. "Insights into the Functions of LncRNAs in Drosophila" Int. J. Mol. Sci. 20, no. 18: 4646. https://doi.org/10.3390/ijms20184646

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