Next Article in Journal
Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling
Next Article in Special Issue
Effects of Extract of Arrabidaea chica Verlot on an Experimental Model of Osteoarthritis
Previous Article in Journal
Endogenous n-3 Polyunsaturated Fatty Acids Are Beneficial to Dampen CD8+ T Cell-Mediated Inflammatory Response upon the Viral Infection in Mice
Previous Article in Special Issue
Animal Models of Inflammation for Screening of Anti-inflammatory Drugs: Implications for the Discovery and Development of Phytopharmaceuticals
Article

Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata

1
Experimental Study of Pain Laboratory, Department of Physiological Sciences, Federal University of Maranhão, São Luís 65080-805, Brazil
2
Laboratory of Pharmacognosy, Department of Pharmacy, Federal University of Maranhão, São Luís 65080-805, Brazil
3
Research Laboratory Information Systems, Department of Information, Environment, Health and Food Production, Federal Institute of Piauí, Teresina 64000-040, Brazil
4
Chemistry Department, Federal University of Maranhão, São Luís 65080-805, Brazil
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(18), 4512; https://doi.org/10.3390/ijms20184512
Received: 25 August 2019 / Revised: 9 September 2019 / Accepted: 9 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue Natural Anti-inflammatory Agents 2019)
The stingless bee, Melipona fasciculata Smith (Apidae, Meliponini), is a native species from Brazil. Their products have high biotechnological potential, however there are no studies about the biological activities of pollen collected by M. fasciculata. In this context, the present study investigated the chemical composition, anti-oxidant, anti-inflammatory, and analgesic activities of hydroethanolic pollen extracts collected by M. fasciculata in three cities in Maranhão State, Brazil. We verified the antioxidant activity of the extracts and inhibitory activity against the cyclooxygenase enzyme using in vitro assays and in allowed to select the extract with higher efficiency to be used on in vivo assays. In these trials, the selected extract showed high anti-inflammatory activity as well as nociceptive effects at central and peripheral level, suggesting that this extract acts on inhibition of histamine release and decreased synthesis of prostaglandins and the in-silico study suggested that polyphenols and acids fatty acids in the extract may be associated with these activities. The results of the present study report the high biological potential of pollen extract and we conclude that the pollen collected by M. fasciculata can be considered as the object of research for new pharmacological alternatives. View Full-Text
Keywords: pollen; extract; pain; anti-inflammatory; natural products; molecular docking pollen; extract; pain; anti-inflammatory; natural products; molecular docking
Show Figures

Figure 1

MDPI and ACS Style

Lopes, A.J.O.; Vasconcelos, C.C.; Pereira, F.A.N.; Silva, R.H.M.; Queiroz, P.F.d.S.; Fernandes, C.V.; Garcia, J.B.S.; Ramos, R.M.; Rocha, C.Q.d.; Lima, S.T.d.J.R.M.; Cartágenes, M.d.S.d.S.; Ribeiro, M.N.d.S. Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata. Int. J. Mol. Sci. 2019, 20, 4512. https://doi.org/10.3390/ijms20184512

AMA Style

Lopes AJO, Vasconcelos CC, Pereira FAN, Silva RHM, Queiroz PFdS, Fernandes CV, Garcia JBS, Ramos RM, Rocha CQd, Lima STdJRM, Cartágenes MdSdS, Ribeiro MNdS. Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata. International Journal of Molecular Sciences. 2019; 20(18):4512. https://doi.org/10.3390/ijms20184512

Chicago/Turabian Style

Lopes, Alberto J.O., Cleydlenne C. Vasconcelos, Francisco A.N. Pereira, Rosa H.M. Silva, Pedro F.d.S. Queiroz, Caio V. Fernandes, João B.S. Garcia, Ricardo M. Ramos, Cláudia Q.d. Rocha, Silvia T.d.J.R.M. Lima, Maria d.S.d.S. Cartágenes, and Maria N.d.S. Ribeiro. 2019. "Anti-Inflammatory and Antinociceptive Activity of Pollen Extract Collected by Stingless Bee Melipona fasciculata" International Journal of Molecular Sciences 20, no. 18: 4512. https://doi.org/10.3390/ijms20184512

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop