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Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System

Faculty of Basic and Biomedical Sciences, Paris Descartes University, INSERM UMRS 1124, 75006 Paris, France
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(17), 4192; https://doi.org/10.3390/ijms20174192
Received: 25 July 2019 / Revised: 14 August 2019 / Accepted: 19 August 2019 / Published: 27 August 2019
(This article belongs to the Special Issue Liver X Receptors)
Recent research in the last decade has sought to explore the role and therapeutic potential of Liver X Receptors (LXRs) in the physiology and pathologies of the Peripheral Nervous System. LXRs have been shown to be important in maintaining the redox homeostasis in peripheral nerves for proper myelination, and they regulate ER stress in sensory neurons. Furthermore, LXR stimulation has a positive impact on abrogating the effects of diabetic peripheral neuropathy and obesity-induced allodynia in the Peripheral Nervous System (PNS). This review details these findings and addresses certain important questions that are yet to be answered. The potential roles of LXRs in different cells of the PNS are speculated based on existing knowledge. The review also aims to provide important perspectives for further research in elucidating the role of LXRs and assessing the potential of LXR based therapies to combat pathologies of the Peripheral Nervous System. View Full-Text
Keywords: LXR; oxysterol; cholesterol; peripheral nervous system; myelin; schwann cell LXR; oxysterol; cholesterol; peripheral nervous system; myelin; schwann cell
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Sundaram, V.K.; Massaad, C.; Grenier, J. Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System. Int. J. Mol. Sci. 2019, 20, 4192.

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