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MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm

Cardiovascular Research Unit, Luxembourg Institute of Health, 1A-B rue Edison, L-1445 Strassen, Luxembourg
Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Richard B. Simches Research Center 185 Cambridge Street Suite 3201, Boston, MA 02114, USA
Surgical Research Center, Department of Cardiovascular and Thoracic Surgery, University Hospital of Liege, Avenue de l’hôpital 1, 4000 Liège, Belgium
UMR1148 INSERM and University Paris Diderot, 46 rue Henri-Huchard, 75877 Paris, France
Author to whom correspondence should be addressed.
On behalf of the Cardiolinc network (
Int. J. Mol. Sci. 2019, 20(16), 3924;
Received: 1 July 2019 / Revised: 7 August 2019 / Accepted: 9 August 2019 / Published: 12 August 2019
(This article belongs to the Special Issue RNAs in Cardiovascular Diseases-CardioRNA EU COST Action)
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Thoracic aortic aneurysm (TAA) can lead to fatal complications such as aortic dissection. Since aneurysm dimension poorly predicts dissection risk, microRNAs (miRNAs) may be useful to diagnose or risk stratify TAA patients. We aim to identify miRNAs associated with TAA pathogenesis and that are possibly able to improve TAA diagnosis. MiRNA microarray experiments of aortic media tissue samples from 19 TAA patients and 19 controls allowed identifying 232 differentially expressed miRNAs. Using interaction networks between these miRNAs and 690 genes associated with TAA, we identified miR-574-5p as a potential contributor of TAA pathogenesis. Interestingly, miR-574-5p was significantly down-regulated in the TAA tissue compared to the controls, but was up-regulated in serum samples from a separate group of 28 TAA patients compared to 20 controls (p < 0.001). MiR-574-5p serum levels discriminated TAA patients from controls with an area under the receiver operating characteristic curve of 0.87. In the Fbn1C1041G/+ mouse model, miR-574-5p was down-regulated in aortic tissue compared to wild-type (p < 0.05), and up-regulated in plasma extracellular vesicles from Fbn1C1041G/+ mice compared to wild-type mice (p < 0.05). Furthermore, in vascular smooth muscle cells, angiotensin II appears to induce miR-574-5p secretion in extracellular vesicles. In conclusion, miR-574-5p is associated with TAA pathogenesis and may help in diagnosing this disease. View Full-Text
Keywords: circulating microRNAs; thoracic aortic aneurysm; biomarker circulating microRNAs; thoracic aortic aneurysm; biomarker

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Boileau, A.; Lino Cardenas, C.L.; Courtois, A.; Zhang, L.; Rodosthenous, R.S.; Das, S.; Sakalihasan, N.; Michel, J.-B.; Lindsay, M.E.; Devaux, Y. MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm. Int. J. Mol. Sci. 2019, 20, 3924.

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