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Glucagon Control on Food Intake and Energy Balance

1
Inserm UMR-S1270, Sorbonne Université, Faculté des Sciences et d’Ingénierie, Institut du Fer a Moulin, 75005 Paris, France
2
Hormone Laboratory, Haukeland University Hospital, N-5020 Bergen, Norway
3
Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
4
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 15706 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(16), 3905; https://doi.org/10.3390/ijms20163905
Received: 17 June 2019 / Revised: 24 July 2019 / Accepted: 8 August 2019 / Published: 11 August 2019
(This article belongs to the Special Issue The Biology and Pharmacology of Glucagon)
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Abstract

Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome. View Full-Text
Keywords: glucagon; energy balance; food intake; body weight; energy expenditure; thermogenesis; lipid metabolism; obesity glucagon; energy balance; food intake; body weight; energy expenditure; thermogenesis; lipid metabolism; obesity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Al-Massadi, O.; Fernø, J.; Diéguez, C.; Nogueiras, R.; Quiñones, M. Glucagon Control on Food Intake and Energy Balance. Int. J. Mol. Sci. 2019, 20, 3905.

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