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Review

Tear Metabolomics in Dry Eye Disease: A Review

1
Department of Medical Biochemistry, Oslo University Hospital, Ullevål, 0450 Oslo, Norway
2
Center for Eye Research, Department of Ophthalmology, Oslo University Hospital, Ullevål, 0450 Oslo, Norway
3
The Norwegian Dry Eye Clinic, 0366 Oslo, Norway
4
Department of Medical Biochemistry, Oslo University Hospital, 0027 Oslo, Norway
5
Department of Plastic and Reconstructive Surgery, Oslo University Hospital, 0450 Oslo, Norway
6
Department of Maxillofacial Surgery, Oslo University Hospital, 0450 Oslo, Norway
7
Department of Ophthalmology, Vestre Viken Hospital Trust, 3019 Drammen, Norway
8
Department of Ophthalmology, Stavanger University Hospital, 4011 Stavanger, Norway
9
Department of Clinical Medicine, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway
10
Department of Ophthalmology, Sørlandet Hospital Arendal, 4604 Arendal, Norway
11
Department of Life Sciences and Health, Oslo Metropolitan University, 0130 Oslo, Norway
12
Department of Computer Sciences, Oslo Metropolitan University, 0130 Oslo, Norway
13
Department of Product Design, Oslo Metropolitan University, 0130 Oslo, Norway
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3755; https://doi.org/10.3390/ijms20153755
Received: 5 July 2019 / Revised: 26 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
(This article belongs to the Special Issue Dry Eye and Ocular Surface Disorders 2.0)
Dry eye disease (DED) is a multifactorial syndrome that can be caused by alteration in the quality or quantity of the precorneal tear film. It is considered one of the most common ocular conditions leading patients to seek eye care. The current method for diagnostic evaluations and follow-up examinations of DED is a combination of clinical signs and symptoms determined by clinical tests and questionnaires, respectively. The application of powerful omics technologies has opened new avenues toward analysis of subjects in health and disease. Metabolomics is a new emerging and complementary research discipline to all modern omics in the comprehensive analysis of biological systems. The identification of distinct metabolites and integrated metabolic profiles in patients can potentially inform clinicians at an early stage or during monitoring of disease progression, enhancing diagnosis, prognosis, and the choice of therapy. In ophthalmology, metabolomics has gained considerable attention over the past decade but very limited such studies have been reported on DED. This paper aims to review the application of tear metabolomics in DED. View Full-Text
Keywords: metabolomics; tear; dry eye disease; ophthalmology metabolomics; tear; dry eye disease; ophthalmology
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MDPI and ACS Style

Yazdani, M.; Elgstøen, K.B.P.; Rootwelt, H.; Shahdadfar, A.; Utheim, Ø.A.; Utheim, T.P. Tear Metabolomics in Dry Eye Disease: A Review. Int. J. Mol. Sci. 2019, 20, 3755. https://doi.org/10.3390/ijms20153755

AMA Style

Yazdani M, Elgstøen KBP, Rootwelt H, Shahdadfar A, Utheim ØA, Utheim TP. Tear Metabolomics in Dry Eye Disease: A Review. International Journal of Molecular Sciences. 2019; 20(15):3755. https://doi.org/10.3390/ijms20153755

Chicago/Turabian Style

Yazdani, Mazyar, Katja B.P. Elgstøen, Helge Rootwelt, Aboulghassem Shahdadfar, Øygunn A. Utheim, and Tor P. Utheim. 2019. "Tear Metabolomics in Dry Eye Disease: A Review" International Journal of Molecular Sciences 20, no. 15: 3755. https://doi.org/10.3390/ijms20153755

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