Chemerin and Cancer
1
Department of Obstetrics and Gynecology, University Medical Center Regensburg, 93053 Regensburg, Germany
2
Department of Internal Medicine I, University Medical Center Regensburg, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(15), 3750; https://doi.org/10.3390/ijms20153750
Received: 2 July 2019
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Revised: 29 July 2019
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Accepted: 30 July 2019
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Published: 31 July 2019
(This article belongs to the Special Issue Adipokines 2.0)
Chemerin is a multifunctional adipokine with established roles in inflammation, adipogenesis and glucose homeostasis. Increasing evidence suggest an important function of chemerin in cancer. Chemerin’s main cellular receptors, chemokine-like receptor 1 (CMKLR1), G-protein coupled receptor 1 (GPR1) and C-C chemokine receptor-like 2 (CCRL2) are expressed in most normal and tumor tissues. Chemerin’s role in cancer is considered controversial, since it is able to exert both anti-tumoral and tumor-promoting effects, which are mediated by different mechanisms like recruiting innate immune defenses or activation of endothelial angiogenesis. For this review article, original research articles on the role of chemerin and its receptors in cancer were considered, which are listed in the PubMed database. Additionally, we included meta-analyses of publicly accessible DNA microarray data to elucidate the association of expression of chemerin and its receptors in tumor tissues with patients’ survival.
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MDPI and ACS Style
Treeck, O.; Buechler, C.; Ortmann, O. Chemerin and Cancer. Int. J. Mol. Sci. 2019, 20, 3750. https://doi.org/10.3390/ijms20153750
AMA Style
Treeck O, Buechler C, Ortmann O. Chemerin and Cancer. International Journal of Molecular Sciences. 2019; 20(15):3750. https://doi.org/10.3390/ijms20153750
Chicago/Turabian StyleTreeck, Oliver, Christa Buechler, and Olaf Ortmann. 2019. "Chemerin and Cancer" International Journal of Molecular Sciences 20, no. 15: 3750. https://doi.org/10.3390/ijms20153750
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