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Open AccessArticle

A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment

Department of Pharmaceutical Science, University of Perugia, 06126 Perugia, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(15), 3634; https://doi.org/10.3390/ijms20153634
Received: 5 July 2019 / Revised: 22 July 2019 / Accepted: 22 July 2019 / Published: 25 July 2019
(This article belongs to the Collection Sphingolipid Signaling in Health and Disease)
The skin has many functions, such as providing a barrier against injury and pathogens, protecting from ultraviolet light, and regulating body temperature. Mechanical causes and many different pathologies can lead to skin damage. Therefore, it is important for the skin to be always adaptable and renewable and for cells to undergo proliferation. Here, we demonstrate that 1α, 25-dihydroxyvitamin D3 (VD3) stimulates keratinocyte proliferation, leading to wound closure in a simulation model of injury. Functionally, our results show that VD3 acts by stimulating cyclin D1, a cyclin that promotes the G1/S transition of the cell cycle. The study on the mechanism underlying cyclin D1 expression upon VD3 stimulation clearly demonstrates a key role of neutral sphingomyelinase. The enzyme, whose gene and protein expression is stimulated by VD3, is itself able to induce effects on cyclin D1 and wound healing similar to those obtained with VD3. These results could be very useful in the future to better understand wound mechanisms and improve therapeutic interventions. View Full-Text
Keywords: cell proliferation; keratinocyte; neutral sphingomyelinase; vitamin D; wound healing repair cell proliferation; keratinocyte; neutral sphingomyelinase; vitamin D; wound healing repair
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MDPI and ACS Style

Patria, F.F.; Ceccarini, M.R.; Codini, M.; Conte, C.; Perioli, L.; Beccari, T.; Albi, E. A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment. Int. J. Mol. Sci. 2019, 20, 3634. https://doi.org/10.3390/ijms20153634

AMA Style

Patria FF, Ceccarini MR, Codini M, Conte C, Perioli L, Beccari T, Albi E. A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment. International Journal of Molecular Sciences. 2019; 20(15):3634. https://doi.org/10.3390/ijms20153634

Chicago/Turabian Style

Patria, Federica F.; Ceccarini, Maria R.; Codini, Michela; Conte, Carmela; Perioli, Luana; Beccari, Tommaso; Albi, Elisabetta. 2019. "A Role for Neutral Sphingomyelinase in Wound Healing Induced by Keratinocyte Proliferation upon 1α, 25-Dihydroxyvitamin D3 Treatment" Int. J. Mol. Sci. 20, no. 15: 3634. https://doi.org/10.3390/ijms20153634

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