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Review

Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy

Institute of Pharmacology, University of Bern, 3010 Bern, Switzerland
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Int. J. Mol. Sci. 2019, 20(15), 3624; https://doi.org/10.3390/ijms20153624
Received: 28 June 2019 / Revised: 22 July 2019 / Accepted: 22 July 2019 / Published: 24 July 2019
(This article belongs to the Special Issue Lipid as a Cancer Therapeutic Target)
The deregulation of cancer cell metabolic networks is now recognized as one of the hallmarks of cancer. Abnormal lipid synthesis and extracellular lipid uptake are advantageous modifications fueling the needs of uncontrolled cancer cell proliferation. Fatty acids are placed at the crossroads of anabolic and catabolic pathways, as they are implicated in the synthesis of phospholipids and triacylglycerols, or they can undergo β-oxidation. Key players to these decisions are the long-chain acyl-CoA synthetases, which are enzymes that catalyze the activation of long-chain fatty acids of 12–22 carbons. Importantly, the long-chain acyl-CoA synthetases are deregulated in many types of tumors, providing a rationale for anti-tumor therapeutic opportunities. The purpose of this review is to summarize the last up-to-date findings regarding their role in cancer, and to discuss the related emerging tumor targeting opportunities. View Full-Text
Keywords: ACSL1; ACSL3; ACSL4; ACSL5; ACSL6; cancer; lipid metabolism; fatty acid; cancer therapy; therapy target ACSL1; ACSL3; ACSL4; ACSL5; ACSL6; cancer; lipid metabolism; fatty acid; cancer therapy; therapy target
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MDPI and ACS Style

Rossi Sebastiano, M.; Konstantinidou, G. Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy. Int. J. Mol. Sci. 2019, 20, 3624. https://doi.org/10.3390/ijms20153624

AMA Style

Rossi Sebastiano M, Konstantinidou G. Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy. International Journal of Molecular Sciences. 2019; 20(15):3624. https://doi.org/10.3390/ijms20153624

Chicago/Turabian Style

Rossi Sebastiano, Matteo; Konstantinidou, Georgia. 2019. "Targeting Long Chain Acyl-CoA Synthetases for Cancer Therapy" Int. J. Mol. Sci. 20, no. 15: 3624. https://doi.org/10.3390/ijms20153624

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