Vaccinations for Colorectal Cancer: Progress, Strategies, and Novel Adjuvants
Round 1
Reviewer 1 Report
The authors have provided exhaustive review on the cancer action and the surrounding mechanism, in addition to the therapeutic options partly in perspective of corectal cancer. The authors might want to consider providing additional information in the figure legends describing statistics and SE or SD and consider using even formatting.
Point 1: The authors might want to consider providing additional information in the figure legends describing statistics and SE or SD
Response 1: Additional information regarding SE, p-value and mean values was provided in the figure 1 legend (227.5 ± 36.4 vs 122.9 ± 12.5, P = 0.02). This will provide readers with specific numbers regarding tumour weights and saves them the trouble of estimating from looking at the graphs. The p-value also assures them in regards to the significance of the results.
Point 2: and consider using even formatting.
Response 2: My references in my literature review had long Griffith URLs, and several do not have URLs.
The journal has posted these instructions:
References should be described as follows, depending on the type of work:
Journal Articles:
1. Author 1, A.B.; Author 2, C.D. Title of the article. Abbreviated Journal Name Year, Volume, page range. Available online: URL (accessed on Day Month Year).
Reviewer 2 Report
This review entitled “ Vaccinations for Colorectal Cancer: Progresses, Strategies, and Novel Adjuvants” describes the recent progress towards understanding the current status of cancer vaccines and the further improvements that can be made through the utilisation of adjuvants. It investigates a wide range of adjuvants and evaluates their effectiveness, with emphasis on the treatment of CRC. It is hypothesized that adjuvants, when combined with cancer vaccines, significantly enhance the immune system's ability to fight cancer synergistically. Synergism occurs when the combined effect of two substances is greater than their individual results. This means that when multiple adjuvants are combined, the resulting treatment will be significantly better.
Authors detail an overview about signaling molecules of the immune system, inhibitors of cancer immune evasion, the advantages and limitations of cancer vaccines and adjuvants and cancer vaccines for easy comprehension when reading.
Author Response
Point 1: This review entitled “ Vaccinations for Colorectal Cancer: Progresses, Strategies, and Novel Adjuvants” describes the recent progress towards understanding the current status of cancer vaccines and the further improvements that can be made through the utilisation of adjuvants. It investigates a wide range of adjuvants and evaluates their effectiveness, with emphasis on the treatment of CRC. It is hypothesized that adjuvants, when combined with cancer vaccines, significantly enhance the immune system's ability to fight cancer synergistically. Synergism occurs when the combined effect of two substances is greater than their individual results. This means that when multiple adjuvants are combined, the resulting treatment will be significantly better.
Authors detail an overview about signaling molecules of the immune system, inhibitors of cancer immune evasion, the advantages and limitations of cancer vaccines and adjuvants and cancer vaccines for easy comprehension when reading.
Response 1: No edits were suggested by the reviewer.
