Next Article in Journal
Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle
Next Article in Special Issue
Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation
Previous Article in Journal
Diagnostic and Treatment Approaches Involving Transthyretin in Amyloidogenic Diseases
Previous Article in Special Issue
Epigenetic Effects of n-3 LCPUFAs: A Role in Pediatric Metabolic Syndrome
Review

Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges

1
Department of Translation Medicine, Federico II University of Naples, 80131 Naples, Italy
2
URT Genomic of Diabetes, Institute of Experimental Endocrinology and Oncology, National Research Council, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2983; https://doi.org/10.3390/ijms20122983
Received: 20 May 2019 / Revised: 13 June 2019 / Accepted: 17 June 2019 / Published: 19 June 2019
(This article belongs to the Special Issue Nutrition, Epigenetics, and Diseases)
A healthy diet improves life expectancy and helps to prevent common chronic diseases such as type 2 diabetes (T2D) and obesity. The mechanisms driving these effects are not fully understood, but are likely to involve epigenetics. Epigenetic mechanisms control gene expression, maintaining the DNA sequence, and therefore the full genomic information inherited from our parents, unchanged. An interesting feature of epigenetic changes lies in their dynamic nature and reversibility. Accordingly, they are susceptible to correction through targeted interventions. Here we will review the evidence supporting a role for nutritional factors in mediating metabolic disease risk through DNA methylation changes. Special emphasis will be placed on the potential of using DNA methylation traits as biomarkers to predict risk of obesity and T2D as well as on their response to dietary and pharmacological (epi-drug) interventions. View Full-Text
Keywords: type 2 diabetes; obesity; DNA methylation; nutritional factors; caloric restriction; high-fat feeding; epigenetic biomarker; personalized medicine; prevention; epigenetic drugs type 2 diabetes; obesity; DNA methylation; nutritional factors; caloric restriction; high-fat feeding; epigenetic biomarker; personalized medicine; prevention; epigenetic drugs
Show Figures

Figure 1

MDPI and ACS Style

Parrillo, L.; Spinelli, R.; Nicolò, A.; Longo, M.; Mirra, P.; Raciti, G.A.; Miele, C.; Beguinot, F. Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges. Int. J. Mol. Sci. 2019, 20, 2983. https://doi.org/10.3390/ijms20122983

AMA Style

Parrillo L, Spinelli R, Nicolò A, Longo M, Mirra P, Raciti GA, Miele C, Beguinot F. Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges. International Journal of Molecular Sciences. 2019; 20(12):2983. https://doi.org/10.3390/ijms20122983

Chicago/Turabian Style

Parrillo, Luca, Rosa Spinelli, Antonella Nicolò, Michele Longo, Paola Mirra, Gregory A. Raciti, Claudia Miele, and Francesco Beguinot. 2019. "Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges" International Journal of Molecular Sciences 20, no. 12: 2983. https://doi.org/10.3390/ijms20122983

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop