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Article

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2918; https://doi.org/10.3390/ijms20122918
Received: 3 May 2019 / Revised: 3 June 2019 / Accepted: 13 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Curcumin in Health and Disease)
Curcumin, a natural polyphenol extracted from a perennial herb Curcuma longa has been verified for many physiological activities such as anti-oxidant, anti-inflammatory, and anti-tumor properties. The direct use of curcumin cytotoxicity studies are limited due to its unstable chemical structure, low bioavailability, easy oxidation, and degradation by ultraviolet (UV) light etc. Trying to overcome this problem, silica-encapsulated curcumin nanoparticles (SCNP) and chitosan with silica co-encapsulated curcumin nanoparticles (CSCNP) were prepared by silicification and biosilicification methods, respectively, and encapsulated curcumin within it. We investigated the antitumor properties of SCNP and CSCNP on different tumor cell lines. Scanning electron microscopy (SEM) analysis revealed that both SCNP and CSCNP were almost spherical in shape and the average particle size of CSCNP was 75.0 ± 14.62 nm, and SCNP was 61.7 ± 23.04 nm. The results show that CSCNP has more anti-oxidant activity as compared to curcumin and SCNP. The higher cytotoxicity towards different cancerous cell lines was also observed in CSCNP treated tumor cells. It was noted that the SCNP and CSCNP has a high percentage of IC50 values in Hep G2 cells. The encapsulation of curcumin improved instability, antioxidant activity, and antitumor activity. Our results demonstrated that nanoencapsulation of curcumin with silica and chitosan not only increase curcumin stability but also enhance its cytotoxic activity on hepatocellular carcinoma cells. On the basis of these primary studies, the curcumin-loaded nanoparticles appear to be promising as an innovative therapeutic material for the treatment of tumors. View Full-Text
Keywords: curcumin; silica; chitosan; nanoparticles; anti-tumor; antioxidant activity curcumin; silica; chitosan; nanoparticles; anti-tumor; antioxidant activity
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MDPI and ACS Style

Kong, Z.-L.; Kuo, H.-P.; Johnson, A.; Wu, L.-C.; Chang, K.L.B. Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells. Int. J. Mol. Sci. 2019, 20, 2918. https://doi.org/10.3390/ijms20122918

AMA Style

Kong Z-L, Kuo H-P, Johnson A, Wu L-C, Chang KLB. Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells. International Journal of Molecular Sciences. 2019; 20(12):2918. https://doi.org/10.3390/ijms20122918

Chicago/Turabian Style

Kong, Zwe-Ling, Hsiang-Ping Kuo, Athira Johnson, Li-Cyuan Wu, and Ke L.B. Chang 2019. "Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells" International Journal of Molecular Sciences 20, no. 12: 2918. https://doi.org/10.3390/ijms20122918

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