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Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain

Dompé Farmaceutici SpA, Via Campo di Pile,67100 L’Aquila, Italy
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Sbarro Institute for Cancer Research and Molecular Medicine and Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 2904;
Received: 10 May 2019 / Revised: 10 June 2019 / Accepted: 12 June 2019 / Published: 14 June 2019
(This article belongs to the Special Issue Chemokines in Cancer and Inflammatory Diseases)
Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports have indicated the involvement of different molecular mechanisms in CIPN. The pathways described so far are diverse and target various components of the peripheral Nervous System (PNS). Among the contributors to neuropathic pain, inflammation has been indicated as a powerful driver of CIPN. Several pieces of evidence have demonstrated a chemotherapy-induced increase in peripheral pro-inflammatory cytokines and a strong correlation with peripheral neuropathy. At present, there are not adequate strategies to prevent CIPN, although there are drugs for treating CIPN, such as duloxetine, that have displayed a moderate effect on CIPN. In this review, we focus on the players involved in CIPN with a particular emphasis on chemokine signaling. View Full-Text
Keywords: chemotherapy; peripheral nervous system; central nervous system; inflammatory mediators; cytokines; chemokines chemotherapy; peripheral nervous system; central nervous system; inflammatory mediators; cytokines; chemokines
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MDPI and ACS Style

Brandolini, L.; d’Angelo, M.; Antonosante, A.; Cimini, A.; Allegretti, M. Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain. Int. J. Mol. Sci. 2019, 20, 2904.

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