Next Article in Journal
A Critical Review of Electroporation as A Plasmid Delivery System in Mouse Skeletal Muscle
Previous Article in Journal
Constitutive Expression of an Apple FLC3-like Gene Promotes Flowering in Transgenic Blueberry under Nonchilling Conditions
Previous Article in Special Issue
Functional Analysis of Peptidyl-prolyl cis-trans Isomerase from Aspergillus flavus
Article Menu
Issue 11 (June-1) cover image

Export Article

Open AccessReview

Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function

1,†, 1,†, 1, 1, 1, 2,* and 1,*
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(11), 2777;
Received: 24 April 2019 / Revised: 31 May 2019 / Accepted: 3 June 2019 / Published: 6 June 2019
PDF [569 KB, uploaded 6 June 2019]


Mycotoxins, which are widely found in feed ingredients and human food, can exert harmful effects on animals and pose a serious threat to human health. As the first barrier against external pollutants, the intestinal mucosa is protected by a mechanical barrier, chemical barrier, immune barrier, and biological barrier. Firstly, mycotoxins can disrupt the mechanical barrier function of the intestinal mucosa, by destroying the morphology and tissue integrity of the intestinal epithelium. Secondly, mycotoxins can cause changes in the composition of mucin monosaccharides and the expression of intestinal mucin, which in turn affects mucin function. Thirdly, mycotoxins can cause damage to the intestinal mucosal immune barrier function. Finally, the microbiotas of animals closely interact with ingested mycotoxins. Based on existing research, this article reviews the effects of mycotoxins on the intestinal mucosal barrier and its mechanisms. View Full-Text
Keywords: mycotoxins; intestinal mucosa; intestinal barrier mycotoxins; intestinal mucosa; intestinal barrier

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Ren, Z.; Guo, C.; Yu, S.; Zhu, L.; Wang, Y.; Hu, H.; Deng, J. Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function. Int. J. Mol. Sci. 2019, 20, 2777.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top