Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function
Zhihua Ren 1,†
, Chaoyue Guo 1,†, Shumin Yu 1, Ling Zhu 1, Ya Wang 1, Hui Hu 2,* and Junliang Deng 1,*
, Chaoyue Guo 1,†, Shumin Yu 1, Ling Zhu 1, Ya Wang 1, Hui Hu 2,* and Junliang Deng 1,*
1
Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China
2
The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(11), 2777; https://doi.org/10.3390/ijms20112777
Received: 24 April 2019 / Revised: 31 May 2019 / Accepted: 3 June 2019 / Published: 6 June 2019
(This article belongs to the Special Issue Biochemistry, Molecular Biology and Toxicology of Natural and Synthetic Toxins)
Abstract
Mycotoxins, which are widely found in feed ingredients and human food, can exert harmful effects on animals and pose a serious threat to human health. As the first barrier against external pollutants, the intestinal mucosa is protected by a mechanical barrier, chemical barrier, immune barrier, and biological barrier. Firstly, mycotoxins can disrupt the mechanical barrier function of the intestinal mucosa, by destroying the morphology and tissue integrity of the intestinal epithelium. Secondly, mycotoxins can cause changes in the composition of mucin monosaccharides and the expression of intestinal mucin, which in turn affects mucin function. Thirdly, mycotoxins can cause damage to the intestinal mucosal immune barrier function. Finally, the microbiotas of animals closely interact with ingested mycotoxins. Based on existing research, this article reviews the effects of mycotoxins on the intestinal mucosal barrier and its mechanisms. View Full-TextKeywords:
mycotoxins; intestinal mucosa; intestinal barrier
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Ren, Z.; Guo, C.; Yu, S.; Zhu, L.; Wang, Y.; Hu, H.; Deng, J. Progress in Mycotoxins Affecting Intestinal Mucosal Barrier Function. Int. J. Mol. Sci. 2019, 20, 2777.
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