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Open AccessReview

p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

1
Department of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133 Rome, Italy
2
Istituto Dermopatico dell’Immacolata, IDI-IRCCS, 00163 Rome, Italy
3
Medical Research Council, Toxicology Unit, University of Cambridge, Cambridge CB2 1PZ, UK
4
National Research Council of Italy, Institute of Translational Pharmacology, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2019, 20(11), 2683; https://doi.org/10.3390/ijms20112683
Received: 13 May 2019 / Revised: 27 May 2019 / Accepted: 29 May 2019 / Published: 31 May 2019
After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, triple-negative breast cancer (TNBC) remains the breast cancer subtype that displays the worst prognosis, mainly due to the lack of clinically actionable targets. Genetic and molecular profiling has unveiled the high intrinsic heterogeneity of TNBC, with the basal-like molecular subtypes representing the most diffuse TNBC subtypes, characterized by the expression of basal epithelial markers, such as the transcription factor p63. In this review, we will provide a broad picture on the physiological role of p63, in maintaining the basal epithelial identity, as well as its involvement in breast cancer progression, emphasizing its relevance in tumor cell invasion and stemness. View Full-Text
Keywords: p53 family; epithelial tumors; TNBC; metastasis; cancer stem cell p53 family; epithelial tumors; TNBC; metastasis; cancer stem cell
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Gatti, V.; Bongiorno-Borbone, L.; Fierro, C.; Annicchiarico-Petruzzelli, M.; Melino, G.; Peschiaroli, A. p63 at the Crossroads between Stemness and Metastasis in Breast Cancer. Int. J. Mol. Sci. 2019, 20, 2683.

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