Adaptive Immunodeficiency in WHIM Syndrome
Abstract
:1. Introduction
2. Lymphoid Organs
2.1. Bone Marrow
2.2. Thymus
2.3. Secondary Lymphoid Organs
3. Lymphocytes
3.1. B Cells
3.2. T Cells
3.3. Natural Killer (NK) Cells
4. The Question of HPV Susceptibility
5. Therapeutic Considerations
Author Contributions
Funding
Conflicts of Interest
Abbreviations
BCR | B-cell receptor |
CLP | Common lymphoid progenitor |
CMJ | Corticomedullary junction |
CMP | Common myeloid progenitor |
DN | Double negative |
DP | Double positive |
G-CSF | Granulocyte colony-stimulating factor |
GVHD | Graft-versus-host disease |
HSC | Hematopoietic stem cell |
HSCT | Hematopoietic stem cell transplantation |
Ig | Immunoglobulin |
LN | Lymph node |
NK | Natural killer |
PCs | Plasma cells |
pDCs | Plasmacytoid dendritic cells |
SCN | Severe congenital neutropenia |
SP | Single positive |
TCR | T-cell receptor |
WHIM | Warts, hypogammaglobulinemia, infections, and myelokathexis |
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Majumdar, S.; Murphy, P.M. Adaptive Immunodeficiency in WHIM Syndrome. Int. J. Mol. Sci. 2019, 20, 3. https://doi.org/10.3390/ijms20010003
Majumdar S, Murphy PM. Adaptive Immunodeficiency in WHIM Syndrome. International Journal of Molecular Sciences. 2019; 20(1):3. https://doi.org/10.3390/ijms20010003
Chicago/Turabian StyleMajumdar, Shamik, and Philip M. Murphy. 2019. "Adaptive Immunodeficiency in WHIM Syndrome" International Journal of Molecular Sciences 20, no. 1: 3. https://doi.org/10.3390/ijms20010003