The Dual Role of MicroRNAs in Colorectal Cancer Progression
Abstract
:1. Introduction
2. MiRNA Biogenesis and Functions
3. The Dual Role of miRNA in CRC
3.1. Oncogenic miRNAs in CRC
3.2. Tumor-Suppressive miRNAs in CRC
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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MiRNA | Direct/Indirect Targets | Functions | Reference |
---|---|---|---|
MiR-21 | PDCD4, TIAM1, SPRY2, PTEN, TGFBR2, CDC25A, hMSH2 | Proliferation, Apoptosis, Invasion, Migration, CSC maintenance, Intravasation, Cell cycle, Chemo-resistance | [23,24,25,26,27] |
MiR-92a | PTEN, SMAD2, SMAD4, TGFBR2 | EMT, Invasion, Venous invasion, Metastases, Proliferation | [29,30] |
MiR-96 | TP53INP1, FOXO1, FOXO3A, UBE2N, XIAP, REV1, RAD51 | Cell growth, Proliferation, Drug-sensitizing, Apoptosis | [32,33,34] |
MiR-135a/b | APC, hMLH1, hMSH2 | Proliferation, Gene dosage effects | [37,38] |
MiR-155 | PTPRJ, TP53INP1, MSH2, MSH6, MLH1, FOXO3a, HuR | Proliferation, Invasion, Stemness, Angiogenesis, Drug resistance, Genome instability, ETM | [42,43,44,45,46,47,48,49] |
MiR-224 | SMAD4, p21, PHLPP1, PHLPP2, GSK-3β | Metastasis, Proliferation, tumorigenicity, Chemoradiosensitivity | [50,51,52,53,54] |
MiR-214 | PTEN, PDLIM2 | Inflammation | [55] |
MiR-31 | RASA1 | Proliferation | [56] |
MiR-210 | RBM3 | Proliferation, Mitochondrial respiration, DNA repair, Vascular biology, Angiogenesis | [57] |
MiR-182/503 | FBXW7 | Malignant transformation | [58] |
MiR-200c | ZEB1, ETS1, FLT1, EMT markers (E-cadherin, vimentin), PTEN | Metastatic, Proliferation, Invasion, Migration | [57,59] |
MiR-301a | TGFBR2 | Lymph node metastasis, Migration, Invasion | [60] |
MiRNA | Direct/Indirect Targets | Functions | Reference |
---|---|---|---|
Let-7 | KRAS | Proliferation | [62,63] |
MiR-194 | MAP4K4, AKT2 | Proliferation, apoptosis, invasion, migration, cell cycle | [65,66] |
MiR-143/145 | IGF1R, CD44, KLF5, KRAS, BRAF | Proliferation, invasion, migration, apoptosis, angiogenesis, chemo-resistance, | [72,76] |
MiR-34a | E2F1, SIRT1, FMNL2, E2F5, SNHG7 | Proliferation, invasiveness, metastasis, apoptosis, chemo-resistance | [80,81,82] |
MiR-126 | PI3K, VCAM-1, CXCR4, VEGFA, IRS1, RhoA | Proliferation, invasion, migration, cell cycle, angiogenesis, hematopoiesis | [89,90,91,92] |
MiR-27b | VEGF, Rab3D | Proliferation, colony formation, angiogenesis, EMT | [97,98] |
MiR-7 | EGFR, RAF-1 | proliferation | [99] |
MiR-18a-3p | KRAS | Proliferation, anchorage-independent growth | [100] |
MiR-26b | TAF12, PTP4A1, CHFR, ALS2CR2, FUT4 | Proliferation, apoptosis, invasiveness, metastasis, migration, chemo-resistance | [101,102] |
MiR-101 | COX-2, ZEB1 | Proliferation, migration | [103,104] |
MiR-144 | mTOR | Proliferation | [105] |
MiR-320a | β-catenin | Proliferation | [106] |
MiR-330 | CDC42 | Proliferation | [107] |
MiR-455 | RAF1 | Proliferation, invasion | [108] |
MiR-149 | FOXM1 | Proliferation, migration, invasion | [109] |
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Ding, L.; Lan, Z.; Xiong, X.; Ao, H.; Feng, Y.; Gu, H.; Yu, M.; Cui, Q. The Dual Role of MicroRNAs in Colorectal Cancer Progression. Int. J. Mol. Sci. 2018, 19, 2791. https://doi.org/10.3390/ijms19092791
Ding L, Lan Z, Xiong X, Ao H, Feng Y, Gu H, Yu M, Cui Q. The Dual Role of MicroRNAs in Colorectal Cancer Progression. International Journal of Molecular Sciences. 2018; 19(9):2791. https://doi.org/10.3390/ijms19092791
Chicago/Turabian StyleDing, Lei, Zhenwei Lan, Xianhui Xiong, Hongshun Ao, Yingting Feng, Huan Gu, Min Yu, and Qinghua Cui. 2018. "The Dual Role of MicroRNAs in Colorectal Cancer Progression" International Journal of Molecular Sciences 19, no. 9: 2791. https://doi.org/10.3390/ijms19092791