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Review

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections

1
IRC-FSH Department of Health Sciences, University “Magna Græcia” of Catanzaro, Campus Universitario di Germaneto, 88100 Catanzaro, Italy
2
Department of Medicine, Chair of Cardiology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
3
IRCCS San Raffaele, Via di Valcannuta 247, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(9), 2693; https://doi.org/10.3390/ijms19092693
Received: 12 July 2018 / Revised: 30 August 2018 / Accepted: 30 August 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Molecular Research on Neurodegenerative Diseases)
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and oligodendrocytes as well as a non-cellular component resulting from the extracellular matrix. The endothelial cells are the major vital components of the BBB able to preserve the brain homeostasis. These cells are situated along the demarcation line between the bloodstream and the brain. Therefore, an alteration or the progressive disruption of the endothelial layer may clearly impair the brain homeostasis. The proper functioning of the brain endothelial cells is generally ensured by two elements: (1) the presence of junction proteins and (2) the preservation of a specific polarity involving an apical-luminal and a basolateral-abluminal membrane. This review intends to identify the molecular mechanisms underlying BBB function and their changes occurring in early stages of neurodegenerative processes in order to develop novel therapeutic strategies aimed to counteract neurodegenerative disorders. View Full-Text
Keywords: brain blood barrier; endothelial dysfunction; neurodegeneration brain blood barrier; endothelial dysfunction; neurodegeneration
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MDPI and ACS Style

Maiuolo, J.; Gliozzi, M.; Musolino, V.; Scicchitano, M.; Carresi, C.; Scarano, F.; Bosco, F.; Nucera, S.; Ruga, S.; Zito, M.C.; Mollace, R.; Palma, E.; Fini, M.; Muscoli, C.; Mollace, V. The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections. Int. J. Mol. Sci. 2018, 19, 2693. https://doi.org/10.3390/ijms19092693

AMA Style

Maiuolo J, Gliozzi M, Musolino V, Scicchitano M, Carresi C, Scarano F, Bosco F, Nucera S, Ruga S, Zito MC, Mollace R, Palma E, Fini M, Muscoli C, Mollace V. The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections. International Journal of Molecular Sciences. 2018; 19(9):2693. https://doi.org/10.3390/ijms19092693

Chicago/Turabian Style

Maiuolo, Jessica, Micaela Gliozzi, Vincenzo Musolino, Miriam Scicchitano, Cristina Carresi, Federica Scarano, Francesca Bosco, Saverio Nucera, Stefano Ruga, Maria C. Zito, Rocco Mollace, Ernesto Palma, Massimo Fini, Carolina Muscoli, and Vincenzo Mollace. 2018. "The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections" International Journal of Molecular Sciences 19, no. 9: 2693. https://doi.org/10.3390/ijms19092693

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