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Decellularized Tissue for Muscle Regeneration

by Anna Urciuolo 1,2 and Paolo De Coppi 2,*
1
Department of Industrial Engineering, University of Padova, 35122 Padova, Italy
2
Great Ormond Street Institute of Child Health, University College of London, London WC1N 1EH, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2392; https://doi.org/10.3390/ijms19082392
Received: 14 July 2018 / Revised: 3 August 2018 / Accepted: 10 August 2018 / Published: 14 August 2018
(This article belongs to the Special Issue Extracellular Matrix in Development and Disease)
Several acquired or congenital pathological conditions can affect skeletal muscle leading to volumetric muscle loss (VML), i.e., an irreversible loss of muscle mass and function. Decellularized tissues are natural scaffolds derived from tissues or organs, in which the cellular and nuclear contents are eliminated, but the tridimensional (3D) structure and composition of the extracellular matrix (ECM) are preserved. Such scaffolds retain biological activity, are biocompatible and do not show immune rejection upon allogeneic or xenogeneic transplantation. An increase number of reports suggest that decellularized tissues/organs are promising candidates for clinical application in patients affected by VML. Here we explore the different strategies used to generate decellularized matrix and their therapeutic outcome when applied to treat VML conditions, both in patients and in animal models. The wide variety of VML models, source of tissue and methods of decellularization have led to discrepant results. Our review study evaluates the biological and clinical significance of reported studies, with the final aim to clarify the main aspects that should be taken into consideration for the future application of decellularized tissues in the treatment of VML conditions. View Full-Text
Keywords: skeletal muscle engineering; tissue engineering; volumetric muscle loss; decellularized tissue; decellularized muscle; acellular tissue; acellular muscle; skeletal muscle regeneration skeletal muscle engineering; tissue engineering; volumetric muscle loss; decellularized tissue; decellularized muscle; acellular tissue; acellular muscle; skeletal muscle regeneration
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MDPI and ACS Style

Urciuolo, A.; De Coppi, P. Decellularized Tissue for Muscle Regeneration. Int. J. Mol. Sci. 2018, 19, 2392.

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