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Review

Retinoid X Receptor Antagonists

Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Int. J. Mol. Sci. 2018, 19(8), 2354; https://doi.org/10.3390/ijms19082354
Received: 12 June 2018 / Revised: 5 August 2018 / Accepted: 7 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Molecular Biology of Nuclear Receptors)
Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research. View Full-Text
Keywords: Retinoid X receptor; RXR; ligands; modulators; antagonists; structural classification; heterodimers; non-permissive; permissive; tRXR Retinoid X receptor; RXR; ligands; modulators; antagonists; structural classification; heterodimers; non-permissive; permissive; tRXR
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MDPI and ACS Style

Watanabe, M.; Kakuta, H. Retinoid X Receptor Antagonists. Int. J. Mol. Sci. 2018, 19, 2354. https://doi.org/10.3390/ijms19082354

AMA Style

Watanabe M, Kakuta H. Retinoid X Receptor Antagonists. International Journal of Molecular Sciences. 2018; 19(8):2354. https://doi.org/10.3390/ijms19082354

Chicago/Turabian Style

Watanabe, Masaki, and Hiroki Kakuta. 2018. "Retinoid X Receptor Antagonists" International Journal of Molecular Sciences 19, no. 8: 2354. https://doi.org/10.3390/ijms19082354

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