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Int. J. Mol. Sci. 2018, 19(8), 2354; https://doi.org/10.3390/ijms19082354

Retinoid X Receptor Antagonists

Division of Pharmaceutical Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1, Tsushima-naka, Kita-ku, Okayama 700-8530, Japan
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Received: 12 June 2018 / Revised: 5 August 2018 / Accepted: 7 August 2018 / Published: 10 August 2018
(This article belongs to the Special Issue Molecular Biology of Nuclear Receptors)
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Abstract

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research. View Full-Text
Keywords: Retinoid X receptor; RXR; ligands; modulators; antagonists; structural classification; heterodimers; non-permissive; permissive; tRXR Retinoid X receptor; RXR; ligands; modulators; antagonists; structural classification; heterodimers; non-permissive; permissive; tRXR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Watanabe, M.; Kakuta, H. Retinoid X Receptor Antagonists. Int. J. Mol. Sci. 2018, 19, 2354.

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