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Int. J. Mol. Sci. 2018, 19(8), 2332; https://doi.org/10.3390/ijms19082332

Clinically Relevant Anti-Inflammatory Agents for Chemoprevention of Colorectal Cancer: New Perspectives

1
Current Address: Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20850, USA
2
Center for Chemoprevention and Drug Development, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
These authors contributed equally.
*
Author to whom correspondence should be addressed.
Received: 19 July 2018 / Revised: 31 July 2018 / Accepted: 3 August 2018 / Published: 8 August 2018
(This article belongs to the Special Issue Inflammation and Cancer 2018)
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Abstract

Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs (NSAIDs) (aspirin, naproxen, sulindac, celecoxib, and licofelone), statins and other natural agents—both individually, and in combinations. Most preclinical trials although were efficacious, only few agents entered clinical trials and have been proven to be potential chemopreventive agents for colon cancer. However, there are limitations for these agents that hinder their approval by the food and drug administration for chemoprevention use in high-risk individuals and in patients with early stages of CRC. In this review, we update the recent advancement in pre-clinical and clinical development of selected anti-inflammatory agents (aspirin, naproxen, sulindac, celecoxib, and licofelone) and their combinations for further development as novel colon cancer chemopreventive drugs. We provide further new perspectives from this old research, and insights into precision medicine strategies to overcome unwanted side-effects and overcoming strategies for colon cancer chemoprevention. View Full-Text
Keywords: colon cancer; chemoprevention; anti-inflammatory agents; NSAIDs colon cancer; chemoprevention; anti-inflammatory agents; NSAIDs
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Mohammed, A.; Yarla, N.S.; Madka, V.; Rao, C.V. Clinically Relevant Anti-Inflammatory Agents for Chemoprevention of Colorectal Cancer: New Perspectives. Int. J. Mol. Sci. 2018, 19, 2332.

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