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Int. J. Mol. Sci. 2018, 19(8), 2294; https://doi.org/10.3390/ijms19082294

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

1
Scientific Direction, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
2
Nuclear Medicine, Hospital HM Modelo, Virrey Osorio 30, 15011 Coruña, Spain
3
Neuropsychology, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
4
Research and Development, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
*
Author to whom correspondence should be addressed.
Received: 4 June 2018 / Revised: 24 July 2018 / Accepted: 31 July 2018 / Published: 5 August 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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Abstract

(1) Background: We analyzed, using PET-SCAN and cognitive tests, how growth hormone (GH) could act in the brain of an older woman, not deficient in GH, who showed mild cognitive alterations (MCI) and had a genotype of ApoE 4/3 and familial dyslipidemia. (2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to knowledge, memory, and behavior was analyzed using 18-F fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day, subcutaneous) for three weeks and on the last day under this treatment, a new PET-SCAN was performed. One month after beginning treatment with GH, a new TAVEC test was performed. (3) Results: GH administration normalized the cognitive deficits observed in the first psychometric test and significantly (p < 0.025) increased the metabolic activity in practically all brain cortical areas, specifically in the left hippocampus and left amygdala, although not in the left parahippocampus. (4) Conclusions: This study demonstrates for the first time the positive effects of GH on cerebral metabolism in a patient without GH deficiency, recovering the function of affected areas related to knowledge, memory, and behavior in an elderly patient with MCI. View Full-Text
Keywords: Growth hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype Growth hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Devesa, J.; Núñez, I.; Agra, C.; Bejarano, A.; Devesa, P. Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype. Int. J. Mol. Sci. 2018, 19, 2294.

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