Next Article in Journal
AAV-Syn-BDNF-EGFP Virus Construct Exerts Neuroprotective Action on the Hippocampal Neural Network during Hypoxia In Vitro
Previous Article in Journal
The Micro-RNA Expression Profiles of Autoimmune Arthritis Reveal Novel Biomarkers of the Disease and Therapeutic Response
Case Report

Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype

1
Scientific Direction, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
2
Nuclear Medicine, Hospital HM Modelo, Virrey Osorio 30, 15011 Coruña, Spain
3
Neuropsychology, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
4
Research and Development, Medical Center Foltra, Travesía de Montouto 24, 15886 Teo, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(8), 2294; https://doi.org/10.3390/ijms19082294
Received: 4 June 2018 / Revised: 24 July 2018 / Accepted: 31 July 2018 / Published: 5 August 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
(1) Background: We analyzed, using PET-SCAN and cognitive tests, how growth hormone (GH) could act in the brain of an older woman, not deficient in GH, who showed mild cognitive alterations (MCI) and had a genotype of ApoE 4/3 and familial dyslipidemia. (2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to knowledge, memory, and behavior was analyzed using 18-F fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day, subcutaneous) for three weeks and on the last day under this treatment, a new PET-SCAN was performed. One month after beginning treatment with GH, a new TAVEC test was performed. (3) Results: GH administration normalized the cognitive deficits observed in the first psychometric test and significantly (p < 0.025) increased the metabolic activity in practically all brain cortical areas, specifically in the left hippocampus and left amygdala, although not in the left parahippocampus. (4) Conclusions: This study demonstrates for the first time the positive effects of GH on cerebral metabolism in a patient without GH deficiency, recovering the function of affected areas related to knowledge, memory, and behavior in an elderly patient with MCI. View Full-Text
Keywords: Growth hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype Growth hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype
Show Figures

Graphical abstract

MDPI and ACS Style

Devesa, J.; Núñez, I.; Agra, C.; Bejarano, A.; Devesa, P. Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype. Int. J. Mol. Sci. 2018, 19, 2294. https://doi.org/10.3390/ijms19082294

AMA Style

Devesa J, Núñez I, Agra C, Bejarano A, Devesa P. Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype. International Journal of Molecular Sciences. 2018; 19(8):2294. https://doi.org/10.3390/ijms19082294

Chicago/Turabian Style

Devesa, Jesús, Iria Núñez, Carlos Agra, Alejandro Bejarano, and Pablo Devesa. 2018. "Treatment with Growth Hormone (GH) Increased the Metabolic Activity of the Brain in an Elder Patient, Not GH-Deficient, Who Suffered Mild Cognitive Alterations and Had an ApoE 4/3 Genotype" International Journal of Molecular Sciences 19, no. 8: 2294. https://doi.org/10.3390/ijms19082294

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop