Next Article in Journal
Hedgehog Signaling Pathway and Autophagy in Cancer
Next Article in Special Issue
Responses of Transgenic Melatonin-Enriched Goats on LPS Stimulation and the Proteogenomic Profiles of Their PBMCs
Previous Article in Journal
Myeloid-Derived Suppressor Cells and Pulmonary Hypertension
Previous Article in Special Issue
Mechanisms Underlying Tumor Suppressive Properties of Melatonin
Open AccessArticle

The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice

1
Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico
2
Laboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico
3
Instituto Politécnico Nacional CNMN Luis Enrique Erro s/n Unidad Profesional Adolfo López Mateos, Gustavo A. Madero, Ciudad de México 07738, Mexico
4
Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo (SUNY), 955 Main Street, Buffalo, NY 14203, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2018, 19(8), 2278; https://doi.org/10.3390/ijms19082278
Received: 7 June 2018 / Revised: 17 July 2018 / Accepted: 20 July 2018 / Published: 3 August 2018
Melatonin is synthesized by the pineal gland with a circadian rhythm in synchrony with the environmental light/dark cycle. A gradual increase in circulating levels of melatonin occur after lights off, reaching its maximum around the middle of the dark phase. Agonists of melatonin receptors have proved effectiveness as antidepressants in clinical trials. However, there is contradictory evidence about the potential antidepressant effect of melatonin itself. Herein we studied melatonin administration in mice at two zeitgeber times (ZT; ZT = 0 lights on; 12:12 L/D), one hour before the beginning (ZT11) and at the middle (ZT18) of the dark phase after either a single or a three-dose protocol. Behavioral despair was assessed through a forced-swimming test (FST) or a tail suspension test (TST), at ZT18.5. A single dose of 4 mg/kg melatonin at ZT11 was effective to reduce the immobility time in both tests. However, acute administration of melatonin at ZT18 was not effective in mice subjected to FST, and a higher dose (16 mg/kg) was required to reduce immobility time in the TST. A three-dose administration protocol of 16 mg/kg melatonin (ZT18, ZT11, and ZT18) significantly reduced immobility time in FST. Data indicate that the timely administration of melatonin could improve its antidepressant-like effect. View Full-Text
Keywords: melatonin; zeitgeber time; antidepressant-like effect; behavioral despair; forced-swimming test; tail suspension test melatonin; zeitgeber time; antidepressant-like effect; behavioral despair; forced-swimming test; tail suspension test
Show Figures

Graphical abstract

MDPI and ACS Style

Estrada-Reyes, R.; Valdés-Tovar, M.; Arrieta-Baez, D.; Dorantes-Barrón, A.M.; Quero-Chávez, D.; Solís-Chagoyán, H.; Argueta, J.; Dubocovich, M.L.; Benítez-King, G. The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice. Int. J. Mol. Sci. 2018, 19, 2278.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop