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Int. J. Mol. Sci. 2018, 19(7), 2054; https://doi.org/10.3390/ijms19072054

Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy

1
Department of Urology, Shiga University of Medical Science, Shiga 520-2192, Japan
2
Department of Clinical Oncology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
3
Central Research Laboratory, Shiga University of Medical Science, Shiga 520-2192, Japan
4
Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520-2192, Japan
5
Peptide Institute Inc., Osaka 567-0085, Japan
6
Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan
*
Authors to whom correspondence should be addressed.
Received: 9 June 2018 / Revised: 12 July 2018 / Accepted: 13 July 2018 / Published: 14 July 2018
(This article belongs to the Special Issue Tumor Targeting Therapy and Selective Killing 2018)
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Abstract

γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers—glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma—and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice. Based on these observations, GGCT is now recognized as a promising therapeutic target in various cancers. This review summarizes recent advances on the mechanisms of the antitumor activity of GGCT inhibition. View Full-Text
Keywords: GGCT; C7orf24; cancer; cellular senescence; autophagy GGCT; C7orf24; cancer; cellular senescence; autophagy
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Kageyama, S.; Ii, H.; Taniguchi, K.; Kubota, S.; Yoshida, T.; Isono, T.; Chano, T.; Yoshiya, T.; Ito, K.; Yoshiki, T.; Kawauchi, A.; Nakata, S. Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy. Int. J. Mol. Sci. 2018, 19, 2054.

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