Next Article in Journal
Scorpins in the DNA Damage Response
Next Article in Special Issue
The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice
Previous Article in Journal
The Expensive-Tissue Hypothesis in Vertebrates: Gut Microbiota Effect, a Review
Previous Article in Special Issue
Fatty Acid β-Oxidation Is Essential in Leptin-Mediated Oocytes Maturation of Yellow Catfish Pelteobagrus fulvidraco
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessReview
Int. J. Mol. Sci. 2018, 19(6), 1793; https://doi.org/10.3390/ijms19061793

Epigenomic Control of Thermogenic Adipocyte Differentiation and Function

1,†
,
1,2,†
,
3
,
2
and
1,4,*
1
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Singapore 138673, Singapore
2
Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, 11 Biopolis Way, Singapore 138667, Singapore
3
Department of Preclinical Development, Translation Medicine and External Research, Jiangsu Hengrui Medicine Co., Ltd., 778 Dongfang Road, Shanghai 200085, China
4
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117596, Singapore
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 21 April 2018 / Revised: 12 June 2018 / Accepted: 12 June 2018 / Published: 17 June 2018
(This article belongs to the Special Issue Transcriptional Regulation in Lipid Metabolism)
Full-Text   |   PDF [1022 KB, uploaded 17 June 2018]   |  

Abstract

Obesity and its associated metabolic disorders are spreading at a fast pace throughout the world; thus, effective therapeutic approaches are necessary to combat this epidemic. Obesity develops when there is a greater caloric intake than energy expenditure. Promoting energy expenditure has recently attracted much attention as a promising approach for the management of body weight. Thermogenic adipocytes are capable of burning fat to dissipate chemical energy into heat, thereby enhancing energy expenditure. After the recent re-discovery of thermogenic adipocytes in adult humans, much effort has focused on understanding the molecular mechanisms, especially the epigenetic mechanisms, which regulate thermogenic adipocyte development and function. A number of chromatin signatures, such as histone modifications, DNA methylation, chromatin accessibilities, and interactions, have been profiled at the genome level and analyzed in various murine and human thermogenic fat cell systems. Moreover, writers and erasers, as well as readers of the epigenome are also investigated using genomic tools in thermogenic adipocytes. In this review, we summarize and discuss the recent advance in these studies and highlight the insights gained into the epigenomic regulation of thermogenic program as well as the pathogenesis of human metabolic diseases. View Full-Text
Keywords: epigenome; thermogenesis; adipocyte; histone modification; DNA methylation epigenome; thermogenesis; adipocyte; histone modification; DNA methylation
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Peng, X.; Zhang, Q.; Liao, C.; Han, W.; Xu, F. Epigenomic Control of Thermogenic Adipocyte Differentiation and Function. Int. J. Mol. Sci. 2018, 19, 1793.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top