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Int. J. Mol. Sci. 2018, 19(6), 1793;

Epigenomic Control of Thermogenic Adipocyte Differentiation and Function

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Singapore 138673, Singapore
Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, A*STAR, 11 Biopolis Way, Singapore 138667, Singapore
Department of Preclinical Development, Translation Medicine and External Research, Jiangsu Hengrui Medicine Co., Ltd., 778 Dongfang Road, Shanghai 200085, China
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117596, Singapore
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 21 April 2018 / Revised: 12 June 2018 / Accepted: 12 June 2018 / Published: 17 June 2018
(This article belongs to the Special Issue Transcriptional Regulation in Lipid Metabolism)
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Obesity and its associated metabolic disorders are spreading at a fast pace throughout the world; thus, effective therapeutic approaches are necessary to combat this epidemic. Obesity develops when there is a greater caloric intake than energy expenditure. Promoting energy expenditure has recently attracted much attention as a promising approach for the management of body weight. Thermogenic adipocytes are capable of burning fat to dissipate chemical energy into heat, thereby enhancing energy expenditure. After the recent re-discovery of thermogenic adipocytes in adult humans, much effort has focused on understanding the molecular mechanisms, especially the epigenetic mechanisms, which regulate thermogenic adipocyte development and function. A number of chromatin signatures, such as histone modifications, DNA methylation, chromatin accessibilities, and interactions, have been profiled at the genome level and analyzed in various murine and human thermogenic fat cell systems. Moreover, writers and erasers, as well as readers of the epigenome are also investigated using genomic tools in thermogenic adipocytes. In this review, we summarize and discuss the recent advance in these studies and highlight the insights gained into the epigenomic regulation of thermogenic program as well as the pathogenesis of human metabolic diseases. View Full-Text
Keywords: epigenome; thermogenesis; adipocyte; histone modification; DNA methylation epigenome; thermogenesis; adipocyte; histone modification; DNA methylation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Peng, X.; Zhang, Q.; Liao, C.; Han, W.; Xu, F. Epigenomic Control of Thermogenic Adipocyte Differentiation and Function. Int. J. Mol. Sci. 2018, 19, 1793.

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