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Open AccessCommunication
Int. J. Mol. Sci. 2018, 19(6), 1633;

Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

Department of Chemistry, Tsinghua University, Beijing 100084, China
Center for Medical Device Evaluation, China Food and Drug Administration, Building 1, Qixiang Road, Beijing 100084, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 15 May 2018 / Accepted: 25 May 2018 / Published: 31 May 2018
(This article belongs to the Special Issue Nucleic Acid Nanotechnology)
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By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa. View Full-Text
Keywords: nucleic acid nanotechnology; DNA nanotechnology; DNA hydrogel nucleic acid nanotechnology; DNA nanotechnology; DNA hydrogel

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liu, H.; Cao, T.; Xu, Y.; Dong, Y.; Liu, D. Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer. Int. J. Mol. Sci. 2018, 19, 1633.

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