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Int. J. Mol. Sci. 2018, 19(6), 1671;

DNA Nanotechnology for Cancer Diagnosis and Therapy

Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, China
Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China
Authors to whom correspondence should be addressed.
Received: 1 May 2018 / Revised: 27 May 2018 / Accepted: 1 June 2018 / Published: 5 June 2018
(This article belongs to the Special Issue Nucleic Acid Nanotechnology)
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Cancer is one of the leading causes of mortality worldwide, because of the lack of accurate diagnostic tools for the early stages of cancer. Thus, early diagnosis, which provides important information for a timely therapy of cancer, is of great significance for controlling the development of the disease and the proliferation of cancer cells and for improving the survival rates of patients. To achieve the goals of early diagnosis and timely therapy of cancer, DNA nanotechnology may be effective, since it has emerged as a valid technique for the fabrication of various nanoscale structures and devices. The resultant DNA-based nanoscale structures and devices show extraordinary performance in cancer diagnosis, owing to their predictable secondary structures, small sizes, and high biocompatibility and programmability. In particular, the rapid development of DNA nanotechnologies, such as molecular assembly technologies, endows DNA-based nanomaterials with more functionalization and intellectualization. Here, we summarize recent progress made in the development of DNA nanotechnology for the fabrication of functional and intelligent nanomaterials and highlight the prospects of this technology in cancer diagnosis and therapy. View Full-Text
Keywords: DNA nanotechnology; cancer; tumor cells; detection; drug delivery DNA nanotechnology; cancer; tumor cells; detection; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Chen, T.; Ren, L.; Liu, X.; Zhou, M.; Li, L.; Xu, J.; Zhu, X. DNA Nanotechnology for Cancer Diagnosis and Therapy. Int. J. Mol. Sci. 2018, 19, 1671.

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