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Int. J. Mol. Sci. 2018, 19(5), 1462; https://doi.org/10.3390/ijms19051462

Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma—A Review

1
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka
2
Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8503, Japan
3
Department of Pathology and Physiopathology, Guilin Medical University, Guilin 541004, China
4
Department of Oral Molecular Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima 770-8504, Japan
*
Author to whom correspondence should be addressed.
Received: 3 April 2018 / Revised: 7 May 2018 / Accepted: 10 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Oral Cancer—Diagnosis and Therapeutics)
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Abstract

It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)—the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood. These topics continue to be very active fields of cancer research. A number of processes, factors, and signaling pathways are involved in regulating invasion and metastasis. However, appropriate clinical trials for anti-cancer drugs targeting the invasion of OSCC are incomplete. In this review, we summarize the recent progress on invasion-related factors and emerging molecular determinants which can be used as potential for diagnostic and therapeutic targets in OSCC. View Full-Text
Keywords: oral squamous cell carcinoma; invasion; metastasis; epithelial mesenchymal transition (EMT); cell adhesion; tumor microenvironment; cell signaling; microRNA oral squamous cell carcinoma; invasion; metastasis; epithelial mesenchymal transition (EMT); cell adhesion; tumor microenvironment; cell signaling; microRNA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Siriwardena, S.B.S.M.; Tsunematsu, T.; Qi, G.; Ishimaru, N.; Kudo, Y. Invasion-Related Factors as Potential Diagnostic and Therapeutic Targets in Oral Squamous Cell Carcinoma—A Review. Int. J. Mol. Sci. 2018, 19, 1462.

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