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Open AccessArticle

The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region

1
Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Barcelona), Spain
2
Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, E-08193 Bellaterra (Barcelona), Spain
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(5), 1384; https://doi.org/10.3390/ijms19051384
Received: 15 April 2018 / Revised: 3 May 2018 / Accepted: 4 May 2018 / Published: 6 May 2018
(This article belongs to the Collection Protein Folding)
Response mechanisms to external stress rely on networks of proteins able to activate specific signaling pathways to ensure the maintenance of cell proteostasis. Many of the proteins mediating this kind of response contain intrinsically disordered regions, which lack a defined structure, but still are able to interact with a wide range of clients that modulate the protein function. Some of these interactions are mediated by specific short sequences embedded in the longer disordered regions. Because the physicochemical properties that promote functional and abnormal interactions are similar, it has been shown that, in globular proteins, aggregation-prone and binding regions tend to overlap. It could be that the same principle applies for disordered protein regions. In this context, we show here that a predicted low-complexity interacting region in the disordered C-terminus of the stress response master regulator heat shock factor 1 (Hsf1) protein corresponds to a cryptic amyloid region able to self-assemble into fibrillary structures resembling those found in neurodegenerative disorders. View Full-Text
Keywords: amyloid; Hsf1; protein aggregation; intrinsically disordered regions; Q/N-rich regions; low complexity; molecular recognition features amyloid; Hsf1; protein aggregation; intrinsically disordered regions; Q/N-rich regions; low complexity; molecular recognition features
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MDPI and ACS Style

Pujols, J.; Santos, J.; Pallarès, I.; Ventura, S. The Disordered C-Terminus of Yeast Hsf1 Contains a Cryptic Low-Complexity Amyloidogenic Region. Int. J. Mol. Sci. 2018, 19, 1384.

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