Next Article in Journal
Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Peroxisomes
Previous Article in Journal
Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome
Open AccessCase Report

Lynch Syndrome-Related Clear Cell Carcinoma of the Cervix: A Case Report

1
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Enyacho 89-1, Izumo 6938501, Japan
2
Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(4), 979; https://doi.org/10.3390/ijms19040979
Received: 13 February 2018 / Revised: 16 March 2018 / Accepted: 21 March 2018 / Published: 25 March 2018
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Lynch syndrome, a hereditary cancer syndrome, occurs because of germline mutations in at least one of four DNA mismatch repair genes (MutL Homolog 1 (MLH1), MutS Homolog 2 (MSH2), MutS Homolog 6 (MSH6), and PMS1 Homolog 2 (PMS2)). The disorder is associated with colorectal, endometrial, and other epithelial malignancies, but not cervical cancer. We report a woman with Lynch syndrome with synchronous cervical cancer. This is the first report of Lynch syndrome-related clear cell carcinoma of the cervix, which indicates the possibility of an association between cervical cancer and Lynch syndrome. Suitable genetic tests are required to determine whether common genetics can account for synchronous or subsequent malignancies in Lynch syndrome patients and their families. Such knowledge will also enhance our understanding of the genetic mechanisms governing the development of apparently unrelated cancers. View Full-Text
Keywords: Lynch syndrome; cervical cancer; immunohistochemistry Lynch syndrome; cervical cancer; immunohistochemistry
Show Figures

Figure 1

MDPI and ACS Style

Nakamura, K.; Nakayama, K.; Minamoto, T.; Ishibashi, T.; Ohnishi, K.; Yamashita, H.; Ono, R.; Sasamori, H.; Razia, S.; Hossain, M.M.; Kamrunnahar, S.; Ishikawa, M.; Ishikawa, N.; Kyo, S. Lynch Syndrome-Related Clear Cell Carcinoma of the Cervix: A Case Report. Int. J. Mol. Sci. 2018, 19, 979.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map

1
Back to TopTop