Next Article in Journal
Tribute to Marcelle Grenson (1925–1996), A Pioneer in the Study of Amino Acid Transport in Yeast
Next Article in Special Issue
Long Non-Coding RNAs Guide the Fine-Tuning of Gene Regulation in B-Cell Development and Malignancy
Previous Article in Journal
Transient Recombinant Protein Production in Glycoengineered Nicotiana benthamiana Cell Suspension Culture
Previous Article in Special Issue
A Comprehensive Analysis of Argonaute-CLIP Data Identifies Novel, Conserved and Species-Specific Targets of miR-21 in Human Liver and Hepatocellular Carcinoma
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2018, 19(4), 1206;

MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells

Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chuncheon 24252, Korea
Department of Physiology and Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA
Authors to whom correspondence should be addressed.
Received: 6 March 2018 / Revised: 4 April 2018 / Accepted: 10 April 2018 / Published: 16 April 2018
Full-Text   |   PDF [5672 KB, uploaded 3 May 2018]   |  


MicroRNAs (miRNAs), a critical part of the RNA silencing machinery, are known to play important regulatory roles in cancer. However, the consequence of miRNA deregulation in cancer is unknown for many miRNAs. Here, we define that miRNAs, miR-17-5p, miR-132-3p/-212-3p, and miR-337-3p are significantly up-regulated in the pancreatic ductal adenocarcinomas (PDAC) compared to the normal and benign tissues. Furthermore, by using PANC-1 cells, we demonstrate that overexpressed miR-337-3p and miR-17-5p/miR-132-3p/-212-3p can regulate executioner caspases-3 and -7, respectively. In addition, over-expression of miRNAs, especially miR-337-3p, attenuates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in PANC-1 cells. Our findings unveil an important biological function for miRNAs up-regulated in PDAC in coordinately regulating caspases, potentially contributing to the malignant progression of PDAC. View Full-Text
Keywords: microRNA; caspase-3; caspase-7; TRAIL; pancreatic adenocarcinomas microRNA; caspase-3; caspase-7; TRAIL; pancreatic adenocarcinomas

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Park, J.K.; Doseff, A.I.; Schmittgen, T.D. MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells. Int. J. Mol. Sci. 2018, 19, 1206.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top