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Int. J. Mol. Sci. 2018, 19(3), 788; https://doi.org/10.3390/ijms19030788

Venomics-Accelerated Cone Snail Venom Peptide Discovery

IMB Centre for Pain Research, Institute for Molecular Bioscience, The University of Queensland, Queensland 4072, Australia
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Received: 18 January 2018 / Revised: 21 February 2018 / Accepted: 21 February 2018 / Published: 9 March 2018
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Abstract

Cone snail venoms are considered a treasure trove of bioactive peptides. Despite over 800 species of cone snails being known, each producing over 1000 venom peptides, only about 150 unique venom peptides are structurally and functionally characterized. To overcome the limitations of the traditional low-throughput bio-discovery approaches, multi-omics systems approaches have been introduced to accelerate venom peptide discovery and characterisation. This “venomic” approach is starting to unravel the full complexity of cone snail venoms and to provide new insights into their biology and evolution. The main challenge for venomics is the effective integration of transcriptomics, proteomics, and pharmacological data and the efficient analysis of big datasets. Novel database search tools and visualisation techniques are now being introduced that facilitate data exploration, with ongoing advances in related omics fields being expected to further enhance venomics studies. Despite these challenges and future opportunities, cone snail venomics has already exponentially expanded the number of novel venom peptide sequences identified from the species investigated, although most novel conotoxins remain to be pharmacologically characterised. Therefore, efficient high-throughput peptide production systems and/or banks of miniaturized discovery assays are required to overcome this bottleneck and thus enhance cone snail venom bioprospecting and accelerate the identification of novel drug leads. View Full-Text
Keywords: cone snails; venom; venomics; proteomics; transcriptomics; visualisation cone snails; venom; venomics; proteomics; transcriptomics; visualisation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Himaya, S.W.A.; Lewis, R.J. Venomics-Accelerated Cone Snail Venom Peptide Discovery. Int. J. Mol. Sci. 2018, 19, 788.

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