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Plant Mitochondrial Inner Membrane Protein Insertion
 
 
Review

The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants

Instituto de Agrobiotecnología del Litoral (CONICET-UNL), Cátedra de Biología Celular y Molecular, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, 3000 Santa Fe, Argentina
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Int. J. Mol. Sci. 2018, 19(3), 662; https://doi.org/10.3390/ijms19030662
Received: 8 January 2018 / Revised: 26 January 2018 / Accepted: 29 January 2018 / Published: 27 February 2018
(This article belongs to the Special Issue Plant Mitochondria)
Mitochondrial respiration is an energy producing process that involves the coordinated action of several protein complexes embedded in the inner membrane to finally produce ATP. Complex IV or Cytochrome c Oxidase (COX) is the last electron acceptor of the respiratory chain, involved in the reduction of O2 to H2O. COX is a multimeric complex formed by multiple structural subunits encoded in two different genomes, prosthetic groups (heme a and heme a3), and metallic centers (CuA and CuB). Tens of accessory proteins are required for mitochondrial RNA processing, synthesis and delivery of prosthetic groups and metallic centers, and for the final assembly of subunits to build a functional complex. In this review, we perform a comparative analysis of COX composition and biogenesis factors in yeast, mammals and plants. We also describe possible external and internal factors controlling the expression of structural proteins and assembly factors at the transcriptional and post-translational levels, and the effect of deficiencies in different steps of COX biogenesis to infer the role of COX in different aspects of plant development. We conclude that COX assembly in plants has conserved and specific features, probably due to the incorporation of a different set of subunits during evolution. View Full-Text
Keywords: mETC; OXPHOS; COX; plant growth; biogenesis mETC; OXPHOS; COX; plant growth; biogenesis
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MDPI and ACS Style

Mansilla, N.; Racca, S.; Gras, D.E.; Gonzalez, D.H.; Welchen, E. The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants. Int. J. Mol. Sci. 2018, 19, 662. https://doi.org/10.3390/ijms19030662

AMA Style

Mansilla N, Racca S, Gras DE, Gonzalez DH, Welchen E. The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants. International Journal of Molecular Sciences. 2018; 19(3):662. https://doi.org/10.3390/ijms19030662

Chicago/Turabian Style

Mansilla, Natanael, Sofia Racca, Diana E. Gras, Daniel H. Gonzalez, and Elina Welchen. 2018. "The Complexity of Mitochondrial Complex IV: An Update of Cytochrome c Oxidase Biogenesis in Plants" International Journal of Molecular Sciences 19, no. 3: 662. https://doi.org/10.3390/ijms19030662

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