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Int. J. Mol. Sci. 2018, 19(2), 459; https://doi.org/10.3390/ijms19020459

Epigenetics and MicroRNAs in Cancer

1,2,†
,
1,2,†
,
1,2,* and 1,2,*
1
Ageing Research Center and Translational Medicine-CeSI-MeT, 66100 Chieti, Italy
2
Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University Chieti-Pescara, 66100 Chieti, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 15 January 2018 / Revised: 29 January 2018 / Accepted: 30 January 2018 / Published: 3 February 2018
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Abstract

The ability to reprogram the transcriptional circuitry by remodeling the three-dimensional structure of the genome is exploited by cancer cells to promote tumorigenesis. This reprogramming occurs because of hereditable chromatin chemical modifications and the consequent formation of RNA-protein-DNA complexes that represent the principal actors of the epigenetic phenomena. In this regard, the deregulation of a transcribed non-coding RNA may be both cause and consequence of a cancer-related epigenetic alteration. This review summarizes recent findings that implicate microRNAs in the aberrant epigenetic regulation of cancer cells. View Full-Text
Keywords: microRNAs; epigenetics; human cancer microRNAs; epigenetics; human cancer
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ramassone, A.; Pagotto, S.; Veronese, A.; Visone, R. Epigenetics and MicroRNAs in Cancer. Int. J. Mol. Sci. 2018, 19, 459.

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