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Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine

Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, Dar Al Uloom University, P.O. Box 45142, Riyadh 11512, Saudi Arabia
Department of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah, Al Munawwarah 41311, Saudi Arabia
Department of Dental Materials, Islamic International Dental College, Riphah International University, Islamabad 44000, Pakistan
Restorative Dental Sciences, Al-Farabi Colleges, Riyadh 361724, Saudi Arabia
College of Dentistry, King Faisal University, P.O. Box 380, Al-Hofuf, Al-Ahsa 31982, Saudi Arabia
Department of Preventive Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh 11512, Saudi Arabia
Department of Dental Materials, College of Dentistry, Jinnah Sindh Medical University, Karachi 75110, Pakistan
Materials Science and Engineering Department, Kroto Research Institute, University of Sheffield, Sheffield S3 7HQ, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2018, 19(2), 407;
Received: 6 December 2017 / Revised: 22 January 2018 / Accepted: 24 January 2018 / Published: 30 January 2018
(This article belongs to the Special Issue Novel Biomaterials for Tissue Engineering 2018)
PDF [9445 KB, uploaded 30 January 2018]


Electrospinning has been used for decades to generate nano-fibres via an electrically charged jet of polymer solution. This process is established on a spinning technique, using electrostatic forces to produce fine fibres from polymer solutions. Amongst, the electrospinning of available biopolymers (silk, cellulose, collagen, gelatine and hyaluronic acid), chitosan (CH) has shown a favourable outcome for tissue regeneration applications. The aim of the current review is to assess the current literature about electrospinning chitosan and its composite formulations for creating fibres in combination with other natural polymers to be employed in tissue engineering. In addition, various polymers blended with chitosan for electrospinning have been discussed in terms of their potential biomedical applications. The review shows that evidence exists in support of the favourable properties and biocompatibility of chitosan electrospun composite biomaterials for a range of applications. However, further research and in vivo studies are required to translate these materials from the laboratory to clinical applications. View Full-Text
Keywords: chitosan; composite solutions; electrospinning; regeneration; tissue engineering chitosan; composite solutions; electrospinning; regeneration; tissue engineering

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Qasim, S.B.; Zafar, M.S.; Najeeb, S.; Khurshid, Z.; Shah, A.H.; Husain, S.; Rehman, I.U. Electrospinning of Chitosan-Based Solutions for Tissue Engineering and Regenerative Medicine. Int. J. Mol. Sci. 2018, 19, 407.

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