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How Glucocorticoids Affect the Neutrophil Life

Department of Medicine, Section of Pharmacology, University of Perugia, 06129 Perugia, Italy
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Int. J. Mol. Sci. 2018, 19(12), 4090; https://doi.org/10.3390/ijms19124090
Received: 30 November 2018 / Revised: 13 December 2018 / Accepted: 15 December 2018 / Published: 17 December 2018
Glucocorticoids are hormones that regulate several functions in living organisms and synthetic glucocorticoids are the most powerful anti-inflammatory pharmacological tool that is currently available. Although glucocorticoids have an immunosuppressive effect on immune cells, they exert multiple and sometimes contradictory effects on neutrophils. From being extremely sensitive to the anti-inflammatory effects of glucocorticoids to resisting glucocorticoid-induced apoptosis, neutrophils are proving to be more complex than they were earlier thought to be. The aim of this review is to explain these complex pathways by which neutrophils respond to endogenous or to exogenous glucocorticoids, both under physiological and pathological conditions. View Full-Text
Keywords: glucocorticoids; neutrophils; inflammation; innate immunity glucocorticoids; neutrophils; inflammation; innate immunity
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MDPI and ACS Style

Ronchetti, S.; Ricci, E.; Migliorati, G.; Gentili, M.; Riccardi, C. How Glucocorticoids Affect the Neutrophil Life. Int. J. Mol. Sci. 2018, 19, 4090.

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